The impact of Toll-like receptors on bacterial virulence strategies Journal Article
| Authors: | Arpaia, N.; Barton, G. M. |
| Article Title: | The impact of Toll-like receptors on bacterial virulence strategies |
| Abstract: | The mammalian immune system has evolved in the presence of microbes, both pathogenic and commensal. The consequences of microbial recognition by the host has led to the development of compensatory mechanisms by both the host and microbe to either resist or tolerate the existence of the other. In this review we discuss examples of this co-evolutionary relationship. Because of space considerations and for conceptual clarity, we have focused on detection of bacteria by the Toll-like receptor (TLR) family and highlight examples of bacterial strategies to evade, subvert and in some cases even utilize these receptors. © 2012 Elsevier Ltd. |
| Keywords: | signal transduction; review; nonhuman; mammalia; stress activated protein kinase; bacterial virulence; bacteria (microorganisms); toll like receptor 4; innate immunity; staphylococcus aureus; helicobacter pylori; myeloid differentiation factor 88; toll like receptor; toll-like receptors; toll like receptor 9; immune evasion; bacteria; biological evolution; toll like receptor 5; host-pathogen interactions; salmonella; streptococcus pyogenes; tumor necrosis factor receptor associated factor 6; yersinia; campylobacter; interferon regulatory factor 3; toll like receptor 7; toll like receptor 8; shigella flexneri; lipid a; toll like receptor 3; beta defensin; bartonella; brucella abortus; brucella suis; enteropathogenic escherichia coli; yersinia pestis |
| Journal Title: | Current Opinion in Microbiology |
| Volume: | 16 |
| Issue: | 1 |
| ISSN: | 1369-5274 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-02-01 |
| Start Page: | 17 |
| End Page: | 22 |
| Language: | English |
| PROVIDER: | scopus |
| PMCID: | PMC3622189 |
| PUBMED: | 23290772 |
| DOI: | 10.1016/j.mib.2012.11.004 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2013" - "CODEN: COMIF" - ":doi 10.1016/j.mib.2012.11.004" - "Source: Scopus" |
