Clinical predictors of a diagnosis of idiopathic pulmonary fibrosis Journal Article
| Authors: | Fell, C. D.; Martinez, F. J.; Liu, L. X.; Murray, S.; Han, M. K.; Kazerooni, E. A.; Gross, B. H.; Myers, J.; Travis, W. D.; Colby, T. V.; Toews, G. B.; Flaherty, K. R. |
| Article Title: | Clinical predictors of a diagnosis of idiopathic pulmonary fibrosis |
| Abstract: | Rationale: Idiopathic pulmonary fibrosis (IPF) and other idiopathic interstitial pneumonias (IIPs) have similar clinical and radiographic features, but their histopathology, response to therapy, and natural history differ. A surgical lung biopsy is often required to distinguish between these entities. Objectives: We sought to determine if clinical variables could predict a histopathologic diagnosis of IPF in patients without honeycomb change on high-resolution computed tomography (HRCT). Methods: Data from 97 patients with biopsy-proven IPF and 38 patients with other IIPs were examined. Logistic regression models were built to identify the clinical variables that predict histopathologic diagnosis of IPF. Measurements and Main Results: Increasing age and average total HRCT interstitial score on HRCT scan of the chest may predict a biopsy confirmation of IPF. Sex, pulmonary function, presence of desaturation, or distance walked during a 6-minute walk test did not help discriminate pulmonary fibrosis from other IIPs. Conclusions: Clinical data may be used to predict a diagnosis of IPF over other IIPs. Validation of these data with a prospective study is needed. |
| Keywords: | adult; controlled study; human tissue; middle aged; retrospective studies; major clinical study; histopathology; methodology; diagnostic accuracy; sensitivity and specificity; reproducibility; reproducibility of results; computer assisted tomography; statistics; diagnosis, differential; observer variation; differential diagnosis; tomography, x-ray computed; age factors; pathology; retrospective study; biopsy; age; diagnosis; lung; prediction and forecasting; predictive value of tests; radiography; aging; fibrosing alveolitis; sex difference; lung function; walking; exercise test; idiopathic pulmonary fibrosis; lung function test; lung fibrosis; interstitial pneumonia; idiopathic interstitial pneumonias; respiratory function tests; computed tomography of the chest; idiopathic interstitial pneumonia; idiopathic disease |
| Journal Title: | American Journal of Respiratory and Critical Care Medicine |
| Volume: | 181 |
| Issue: | 8 |
| ISSN: | 1073-449X |
| Publisher: | American Thoracic Society |
| Date Published: | 2010-04-15 |
| Start Page: | 832 |
| End Page: | 837 |
| Language: | English |
| DOI: | 10.1164/rccm.200906-0959OC |
| PUBMED: | 20056903 |
| PROVIDER: | scopus |
| PMCID: | PMC2854332 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "CODEN: AJCME" - "Source: Scopus" |
