Interstitial lung disease Journal Article
| Author: | Travis, W. D. |
| Article Title: | Interstitial lung disease |
| Abstract: | Idiopathic interstitial pneumonias represent an important group of interstitial lung diseases, encompassing seven entities: (1) usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis; (2) non-specific interstitial pneumonia (NSIP); (3) organizing pneumonia/cryptogenic organizing pneumonia (COP); (4) diffuse alveolar damage (DAD)/acute interstitial pneumonia (AIP); (5) respiratory bronchiolitis (RB)/respiratory bronchiolitis-interstitial lung disease (RB-ILD); (6) desquamative interstitial pneumonia (DIP); and (7) lymphocytic interstitial pneumonia (LIP). The term idiopathic means that the cause is not certain at the time of diagnosis, but each of these patterns of interstitial pneumonia can occur in the setting of known causes as well. This review will highlight the pathological features and differential diagnosis of interstitial pneumonias, along with the high-resolution computed tomography (HRCT) scan and clinical features, emphasizing the importance of clinical, radiological and pathological correlation to establish the correct diagnosis. Familiarity with the histological patterns of lung injury in these disorders will aid pathologists in recognizing the correct diagnosis. It is also important for pathologists and clinicians to understand the settings in which HRCT can overrule pathological findings. In particular, if an HRCT scan shows classical features of UIP, despite surgical biopsy findings of NSIP, the clinical-radiological-pathological diagnosis would be UIP. © 2008. |
| Keywords: | unclassified drug; overall survival; disease course; histopathology; cigarette smoking; cancer grading; edema; computer assisted tomography; differential diagnosis; inflammation; smoking cessation; cyclophosphamide; steroid; allogenic bone marrow transplantation; biopsy; inflammatory cell; coughing; dyspnea; pneumonia; thromboembolism; lymphoma; lung; collagen; fibroblast; interstitial lung disease; fibrosing alveolitis; azathioprine; acquired immune deficiency syndrome; antiretrovirus agent; highly active antiretroviral therapy; inflammatory infiltrate; lymphocytic infiltration; corticosteroid; lung function; macrophage; immunosuppressive treatment; cyclosporin a; lymphoid tissue; idiopathic pulmonary fibrosis; lung biopsy; lung function test; lung fibrosis; cyclosporin; sildenafil; phenytoin; cell hyperplasia; vascular disease; lung alveolus macrophage; lung transplantation; lung lesion; gamma1b interferon; lymphoid hyperplasia; fibrin; connective tissue; interstitial pneumonia; transbronchial biopsy; lung parenchyma; human immunodeficiency virus infected patient; bronchiolitis; high resolution computer tomography; lung injury; bronchiectasis; eosinophil; amiodarone; emphysema; loeffler pneumonia; organizing pneumonia; high-resolution ct; usual interstitial pneumonia; antifibrotic agent; lung alveolus epithelium; pneumocystis jiroveci; bronchiolitis obliterans organizing pneumonia; lung alveolus cell type 2; acetylcysteine; nonspecific interstitial pneumonia; gram staining; pneumocystis carinii; acute interstitial pneumonia; cryptogenic organizing pneumonia; desquamative interstitial pneumonia; diffuse alveolar damage; lymphocytic interstitial pneumonia; non- specific interstitial pneumonia; respiratory bronchiolitis; hemosiderin; perfinidone; acid fast bacterium; bronchodilatation; chronic active hepatitis; clubbing fingers; collagen disease; desquamative pneumonia; hyaline degeneration; hyaline membrane disease; legionella pneumophila; lung alveolus wall |
| Journal Title: | Diagnostic Histopathology |
| Volume: | 14 |
| Issue: | 10 |
| ISSN: | 1756-2317 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-10-01 |
| Start Page: | 499 |
| End Page: | 508 |
| Language: | English |
| DOI: | 10.1016/j.mpdhp.2008.07.009 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 November 2011" - "Source: Scopus" |
