Current dyspnea among long-term survivors of early-stage non-small cell lung cancer Journal Article

Authors: Feinstein, M. B.; Krebs, P.; Coups, E. J.; Park, B. J.; Steingart, R. M.; Burkhalter, J.; Logue, A.; Ostroff, J. S.
Article Title: Current dyspnea among long-term survivors of early-stage non-small cell lung cancer
Abstract: Introdution: Dyspnea is common among lung cancer patients. As most studies of dyspnea have reviewed patients with active cancer or immediately after treatment, its prevalence during the longer-term period once treatment has been completed is not well characterized. This study quantifies the prevalence of dyspnea among lung cancer survivors and identifies potential correlates that may be amenable to intervention. Methods:Cross-sectional survey of 342 patients with disease-free, stage I, non-small cell lung cancer, assessed 1 to 6 years after surgical resection. Dyspnea was quantified using the Baseline Dyspnea Index. Any moderate/strenuous physical activity was measured using the Godin Leisure-Time Exercise Questionnaire. Mood disorder symptoms were assessed using the Hospital Anxiety and Depression Scale. Multiple regression analyses were used to examine demographic, medical, and health-related correlates of dyspnea. Results: Mean age was 68.9 years. Average predicted preoperative forced expiratory volume in 1 second was 89.0%. Current dyspnea, defined by a Baseline Dyspnea Index score of 9 or less, existed among 205 (60%) individuals. For 133 (65%) of these patients, dyspnea was absent preoperatively. Multivariate correlates of current dyspnea included preoperative dyspnea (odds ratio [OR] = 5.31), preoperative diffusing capacity (OR = 0.98), lack of moderate/strenuous physical activity (OR = 0.41), and the presence of clinically significant depression symptoms (OR = 4.10). Conclusions: Dyspnea is common 1 to 6 years after lung cancer resection, and is associated with the presence of preoperative dyspnea, reduced diffusing capacity, clinically significant depression symptoms, and lack of physical activity. Further research is needed to test whether strategies that identify and treat patients with these conditions attenuate dyspnea among lung cancer survivors. © 2010 by the International Association for the Study of Lung Cancer.
Keywords: adult; cancer survival; aged; cancer surgery; major clinical study; cancer staging; disease association; lung non small cell cancer; prevalence; survivors; dyspnea; depression; early cancer; scoring system; carcinoma; disease free interval; cross-sectional study; physical activity; forced expiratory volume; non-small cell lung; lung diffusion capacity
Journal Title: Journal of Thoracic Oncology
Volume: 5
Issue: 8
ISSN: 1556-0864
Publisher: Elsevier Inc.  
Date Published: 2010-08-01
Start Page: 1221
End Page: 1226
Language: English
DOI: 10.1097/JTO.0b013e3181df61c8
PROVIDER: scopus
PUBMED: 20592631
PMCID: PMC4515574
Notes: --- - "Export Date: 20 April 2011" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Jamie S Ostroff
    230 Ostroff
  2. Richard M Steingart
    132 Steingart
  3. Bernard J Park
    173 Park
  4. Amy E Logue
    7 Logue
  5. Paul Krebs
    10 Krebs