Hepatic abnormalities identified on abdominal computed tomography at diagnosis of uveal melanoma Journal Article
| Authors: | Feinstein, E. G.; Marr, B. P.; Winston, C. B.; Abramson, D. H. |
| Article Title: | Hepatic abnormalities identified on abdominal computed tomography at diagnosis of uveal melanoma |
| Abstract: | Objective: To determine the prevalence of hepatic abnormalities identified during abdominal computed tomography (CT) performed within 1 month of the diagnosis of primary uveal melanoma. Methods: Retrospective review of CT reports generated within 1 month following diagnosis of uveal melanoma in 91 patients at Memorial Sloan-Kettering Cancer Center, New York, New York, from 2004 to 2009. Results: Of 198 patients reviewed, 91 (46%) had a CT scan within 1 month of uveal melanoma diagnosis; 1 or more hepatic abnormalities were identified in 50 of these patients (55%). Abnormalities included 38 focal (13 solitary, 25 multiple) and 15 diffuse (11 partial, 4 complete) lesions. Six patients had hepatic lesions suspected to be metastatic melanoma, but this was confirmed in only 3. Lesions suspected to be metastases were more likely multiple than solitary (P=.03). Thirty-nine patients had other lesions, most commonly lesions that were too small to be characterized, a fatty liver, and hepatic cysts. Lesions in 5 of 50 patients with abnormalities could not be classified. Neither the protocol (triphasic vs nontriphasic) nor the center where the scan was performed (Sloan-Kettering vs other) was significantly related to the likelihood of identifying hepatic abnormalities in a given patient (P=.46 and P=.1, respectively). Conclusion: Although hepatic abnormalities were frequently identified in patients who underwent CT within 1 month of uveal melanoma diagnosis, metastatic disease was confirmed only in the setting of multiple lesions in only a minority of patients. ©2010 American Medical Association. All rights reserved. |
| Keywords: | adolescent; adult; controlled study; aged; aged, 80 and over; middle aged; retrospective studies; young adult; major clinical study; liver neoplasms; cancer diagnosis; melanoma; computer assisted tomography; prevalence; tomography, x-ray computed; medical record review; liver metastasis; abdomen; liver disease; liver diseases; uvea melanoma; uveal neoplasms; abdominal radiography; fatty liver; liver cyst |
| Journal Title: | Archives of Ophthalmology |
| Volume: | 128 |
| Issue: | 3 |
| ISSN: | 0003-9950 |
| Publisher: | American Medical Association |
| Date Published: | 2010-03-01 |
| Start Page: | 319 |
| End Page: | 323 |
| Language: | English |
| DOI: | 10.1001/archophthalmol.2009.401 |
| PUBMED: | 20212202 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: AROPA" - "Source: Scopus" |
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