Variates of survival in metastatic uveal melanoma Journal Article

Authors: Rietschel, P.; Panageas, K. S.; Hanlon, C.; Patel, A.; Abramson, D. H.; Chapman, P. B.
Article Title: Variates of survival in metastatic uveal melanoma
Abstract: Purpose: The course and outcome of metastatic uveal melanoma are not well described. We evaluated the survival of our patients with metastatic uveal melanoma, described factors that correlated with survival, and evaluated the influence of screening tests on time of detection and survival. Patients and Methods: All patients with metastatic uveal melanoma seen at Memorial Sloan-Kettering Cancer Center between 1994 and 2004 were identified from our database. We recorded date of initial diagnosis, date of metastatic disease, date of last follow-up, site of the first metastasis, how the first metastasis was discovered, treatment, and outcome of therapy. Results: The estimated median survival of the 119 patients analyzed was 12.5 months; 22% of patients were alive at 4 years. Five variates correlated independently with prolonged survival: Lung/soft tissue as only site of first metastasis, treatment with surgery or intrahepatic therapy, female sex, age younger than 60, and a longer interval from initial diagnosis to metastatic disease. Discovering metastatic disease in asymptomatic patients did not correlate with overall survival; 89% of patients had a single organ as the site of first metastasis. Although liver was the most common site, 39.5% of patients had nonliver sites, most commonly lung, as the first site of metastasis. Conclusion: A substantial subset of patients with metastatic uveal melanoma survive more than 4 years with metastatic disease. Data on variates of survival and site of first metastasis may guide strategies for screening patients, although our data failed to show a survival advantage in discovering asymptomatic metastatic disease. © 2005 by American Society of Clinical Oncology.
Keywords: adult; cancer chemotherapy; cancer survival; controlled study; aged; aged, 80 and over; middle aged; cancer surgery; survival rate; retrospective studies; major clinical study; mortality; cancer localization; multimodality cancer therapy; combined modality therapy; follow up; follow-up studies; lymph node metastasis; antineoplastic agent; lymphatic metastasis; melanoma; metastasis; antineoplastic combined chemotherapy protocols; incidence; cancer screening; pathology; retrospective study; time; time factors; antiinfective agent; immunotherapy; remission; remission induction; immunomodulating agent; uvea melanoma; uvea tumor; uveal neoplasms
Journal Title: Journal of Clinical Oncology
Volume: 23
Issue: 31
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2005-11-01
Start Page: 8076
End Page: 8080
Language: English
DOI: 10.1200/jco.2005.02.6534
PUBMED: 16258106
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 46" - "Export Date: 24 October 2012" - "CODEN: JCOND" - "Source: Scopus"
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MSK Authors
  1. David H Abramson
    255 Abramson
  2. Paul Chapman
    252 Chapman
  3. Katherine S Panageas
    331 Panageas
  4. Ami Patel
    24 Patel
  5. Christine C Hanlon
    9 Hanlon