Prognosis of mucosal, uveal, acral, nonacral cutaneous, and unknown primary melanoma from the time of first metastasis Journal Article


Authors: Kuk, D.; Shoushtari, A. N.; Barker, C. A.; Panageas, K. S.; Munhoz, R. R.; Momtaz, P.; Ariyan, C. E.; Brady, M. S.; Coit, D. G.; Bogatch, K.; Callahan, M. K.; Wolchok, J. D.; Carvajal, R. D.; Postow, M. A.
Article Title: Prognosis of mucosal, uveal, acral, nonacral cutaneous, and unknown primary melanoma from the time of first metastasis
Abstract: Background. Subtypes of melanoma, such as mucosal, uveal, and acral, are believed to result in worse prognoses than nonacral cutaneous melanoma. After a diagnosis of distant metastatic disease, however, the overall survival of patients with mucosal, uveal, acral, nonacral cutaneous, and unknown primary melanoma has not been directly compared. Materials and Methods. We conducted a single-center, retrospective analysis of 3,454 patients with melanoma diagnosed with distant metastases from 2000 to 2013, identified from a prospectively maintained database. We examined melanoma subtype, date of diagnosis of distant metastases, age at diagnosis of metastasis, gender, and site of melanoma metastases. Results. Of the 3,454 patients (237 with mucosal, 286 with uveal, 2,292 with nonacral cutaneous, 105 with acral cutaneous, and 534 with unknown primary melanoma), 2,594 died. The median follow-up was 46.1 months. The median overall survival for thosewithmucosal, uveal, acral, nonacral cutaneous, and unknown primary melanoma was 9.1, 13.4, 11.4, 11.7, and 10.4 months, respectively. Patients with uvealmelanoma, cutaneous melanoma (acral and nonacral), and unknownprimarymelanoma had similar survival, but patients with mucosal melanoma had worse survival. Patients diagnosed with metastatic melanoma in 2006-2010 and 2011-2013 had better overall survival than patients diagnosed in 2000-2005. In a multivariate model, patients with mucosal melanoma had inferior overall survival compared with patients with the other four subtypes. Conclusion. Additional research and advocacy are needed for patients with mucosal melanoma because of their shorter overall survival in the metastatic setting. Despite distinct tumor biology, the survival was similar for those with metastatic uveal melanoma, acral, nonacral cutaneous, and unknown primary melanoma. © AlphaMed Press 2016.
Keywords: unknown primary melanoma; mucosal melanoma; uveal melanoma; prognosis; acral cutaneous melanoma; nonacral cutaneous melanoma
Journal Title: The Oncologist
Volume: 21
Issue: 7
ISSN: 1083-7159
Publisher: AlphaMed Press  
Date Published: 2016-07-01
Start Page: 848
End Page: 854
Language: English
DOI: 10.1634/theoncologist.2015-0522
PROVIDER: scopus
PMCID: PMC4943393
PUBMED: 27286787
DOI/URL:
Notes: Article -- Export Date: 2 August 2016 -- Source: Scopus
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MSK Authors
  1. Jedd D Wolchok
    665 Wolchok
  2. Michael Andrew Postow
    187 Postow
  3. Christopher Barker
    115 Barker
  4. Margaret Kathleen Callahan
    103 Callahan
  5. Katherine S Panageas
    329 Panageas
  6. Mary Sue Brady
    165 Brady
  7. Charlotte Eielson Ariyan
    78 Ariyan
  8. Daniel Coit
    420 Coit
  9. Deborah Kuk
    81 Kuk
  10. Parisa   Momtaz
    16 Momtaz
  11. Rodrigo Ramella Munhoz
    15 Munhoz