Solitary extramedullary plasmacytoma of the cricoid cartilage-case report Journal Article
| Authors: | Krebs, S.; Ganly, I.; Ghossein, R.; Yang, J.; Yahalom, J.; Schöder, H. |
| Article Title: | Solitary extramedullary plasmacytoma of the cricoid cartilage-case report |
| Abstract: | Solitary plasmacytoma (SP) is an extremely rare form of hematologic malignancy that can be classified as solitary bone plasmacytoma or solitary extramedullary plasmacytoma. Here, we report a patient who presented with progressive shortness of breath and foreign body sensation in his throat. Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) demonstrated an abnormal FDG-avid soft tissue mass arising from the larynx involving the cricoid cartilage without additional suspicious lesions. Histology revealed an abundance of plasma cells; immunohistochemistry was positive for CD138 expression and lambda chains, and negative for CD20. Comprehensive imaging studies and panendoscopy of the ENT tract confirmed solitary disease involvement. Following additional systemic work-up, a diagnosis of extramedullary plasmacytoma was rendered. The patient underwent definitive radiotherapy using intensity-modulated radiation therapy (total dose of 46 Gy, divided in 23 fractions of 200 cGy). Serial PET/CT showed the stepwise resolution of abnormal FDG uptake and resolution of the cricoid cartilage lesion. With 22 months of follow-up, the patient remains free of disease. We describe the rare case of SP presenting as a FDG-avid hypermetabolic soft tissue mass in the cricoid cartilage, which should be considered in the differential diagnosis of laryngeal tumors. Of note, SP is radiosensitive; favorable outcome can be expected once treated with doses of 40-50 Gy. FDG PET/CT is helpful in diagnosis and response assessment for this disease. © 2017 Krebs, Ganly, Ghossein, Yang, Yahalom and Schöder. |
| Keywords: | radiotherapy; plasmacytoma; larynx; cricoid; 18f-fdg-pet/ct |
| Journal Title: | Frontiers in Oncology |
| Volume: | 7 |
| ISSN: | 2234-943X |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2017-11-27 |
| Start Page: | 284 |
| Language: | English |
| DOI: | 10.3389/fonc.2017.00284 |
| PROVIDER: | scopus |
| PMCID: | PMC5711767 |
| PUBMED: | 29230383 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
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