Interstitial laser-induced thermotherapy of the lung: Evaluation of the influence of ablation continuity on ablation size in a swine model Journal Article
| Authors: | Schoellnast, H.; Monette, S.; Ezell, P. C.; Keenee, A.; Quehenberger, F.; Erinjeri, J. P.; Solomon, S. B. |
| Article Title: | Interstitial laser-induced thermotherapy of the lung: Evaluation of the influence of ablation continuity on ablation size in a swine model |
| Abstract: | The purpose of this study was to assess the relationship between size and the continuity of energy application in interstitial laser-induced thermotherapy. Percutaneous computed tomography-guided laser ablation (30 W, 600 nm diode) of the lung was performed in 7 Yorkshire pigs; a total of 42 ablation zones were created. Twenty ablations were performed using a continuous cycle of 2 min (protocol A) and 22 ablations were performed using 4 intermittent cycles with a duration of 1 min for each cycle interrupted by a 10-s stop between the cycles (protocol B). The lung was harvested immediately after euthanasia for gross pathology and histopathologic evaluation. Statistical analysis was performed using the Student t test and the Spearman correlation coefficient. Laser ablation resulted in complete necrosis of variable size of lung. The mean ablation zone dimensions (±SD) were 1.9 (±0.4) cm×1.4 (±0.3) cm for protocol A and 2.2 (±0.5) cm×1.4 (±0.4) cm for protocol B. The size of the necrosis is not significantly different when comparing a continuous 2-min ablation to a 4-cycle intermittent ablation for 1 min each cycle interrupted by a 10-s stop between the cycles (P=0.98 and 0.53, respectively). © 2013 International Cancer Imaging Society. |
| Keywords: | lung; thermal ablation; laser ablation; laser-induced therapy; litt |
| Journal Title: | Cancer Imaging |
| Volume: | 13 |
| Issue: | 1 |
| ISSN: | 1470-7330 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2013-02-22 |
| Start Page: | 8 |
| End Page: | 13 |
| Language: | English |
| DOI: | 10.1102/1470-7330.2013.0002 |
| PROVIDER: | scopus |
| PUBMED: | 23439016 |
| PMCID: | PMC3581868 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 April 2013" - "Source: Scopus" |
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