Temporal evaluation of the microwave ablation zone and comparison of CT and gross sizes during the first month post-ablation in swine lung Journal Article
| Authors: | Kodama, H.; Ueshima, E.; Howk, K.; Lee, S. W.; Erinjeri, J. P.; Solomon, S. B.; Srimathveeravalli, G. |
| Article Title: | Temporal evaluation of the microwave ablation zone and comparison of CT and gross sizes during the first month post-ablation in swine lung |
| Abstract: | Purpose: The purpose of this study was to investigate the development and evolution of the microwave ablation (MWA) lesion in the normal lung by using a swine model at various time points and to compare post-procedural computed tomography (CT) and gross pathologic findings during the first month post-ablation. Materials and methods: Twenty-seven percutaneous MWA procedures were performed on swine lungs at 100 W for either 2 min (low dose, 18 ablations) or 10 min (high dose, 9 ablations). Animals were sacrificed at either 2 days (n = 5) or 28 days (n = 5) after ablation. All animals underwent CT imaging immediate post-treatment and prior to sacrifice, with additional imaging at 7 and 14 days for the 28-day cohort. After euthanasia, lungs and trachea were removed en bloc and underwent gross pathology analysis. Results: In both dose treatment groups, CT measurements of the ablation zone were maximum at Day 7 (low dose: 7.50 ± 3.08 cm 3 ; high dose: 24.87 ± 11.34 cm 3 ) and significantly larger compared to the immediate post-ablation measurements (low dose: 2.54 ± 1.81 cm 3 ; P = 0.00011; high dose: 9.14 ± 3.42 cm 3 ; P = 0.00374). No significant differences in dimensions were observed between CT and gross pathologic images for both high and low dose ablations in both cohorts. Conclusion: The treatment zone following MWA in the lung can vary in the sub-acute setting, achieving largest size at 7 days post-treatment. Furthermore, measurements from CT closely matched with gross pathologic ablation size. © 2018 Société française de radiologie |
| Keywords: | controlled study; nonhuman; drug megadose; low drug dose; computer assisted tomography; animal experiment; animal model; lung; pig; trachea; computed tomography (ct); euthanasia; preclinical study; article; ablation zone; microwave thermotherapy; microwave ablation (mwa) |
| Journal Title: | Diagnostic and Interventional Imaging |
| Volume: | 100 |
| Issue: | 5 |
| ISSN: | 2211-5684 |
| Publisher: | Elsevier Masson |
| Date Published: | 2019-05-01 |
| Start Page: | 279 |
| End Page: | 285 |
| Language: | English |
| DOI: | 10.1016/j.diii.2018.10.008 |
| PUBMED: | 30581098 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 June 2019 -- Source: Scopus |
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