Augmented fluoroscopy guided transbronchial pulmonary microwave ablation using a steerable sheath Journal Article
| Authors: | Ghosn, M.; Elsakka, A. S.; Ridouani, F.; Doustaly, R.; Mingione, L.; Royalty, K.; Ziv, E.; Alexander, E.; Maxwell, A.; Monette, S.; Kim, H. S.; Short, R. F.; Tam, A. L.; Suh, R. D.; Solomon, S. B. |
| Article Title: | Augmented fluoroscopy guided transbronchial pulmonary microwave ablation using a steerable sheath |
| Abstract: | Background: Transbronchial microwave ablation (MWA) is a promising novel therapy. Despite advances in bronchoscopy and virtual navigation, real time image guidance of probe delivery is lacking, and distal maneuverability is limited. Cone-beam computed tomography (CBCT) based augmented fluoroscopy guidance using steerable sheaths may help overcome these shortcomings. The aim of this study was to evaluate feasibility and accuracy of augmented fluoroscopy guided transbronchial MWA with a steerable sheath and without a bronchoscope. Methods: In this prospective study, procedures were performed under general anesthesia. Extra-bronchial lung synthetic targets were placed percutaneously. Target and airways extracted from CBCT, with planned bronchial parking point close to the target were overlaid on live fluoroscopy. Endobronchial navigation was solely performed under augmented fluoroscopy guidance. A 6.5 Fr steerable sheath was parked in the bronchus per plan, and a flexible MWA probe was inserted coaxially then advanced through the bronchus wall towards the target. Final in-target position was confirmed by CBCT. Only one ablation of 100 W-5 min was performed per target. Animals were euthanized and pathology analysis of the lungs was performed. Results: Eighteen targets with a median largest diameter of 9 mm (interquartile range, 7-11 mm) were ablated in 9 pigs. Median needle-target center distance was 2 mm (interquartile range, 0-4 mm), and was higher for lower/middle than for upper lobes [0 mm (interquartile range, 0-4 mm) vs. 4 mm (interquartile range, 3-8 mm), P=0.04]. No severe complications or pneumothorax occurred. Two cases of rib fractures in the ablation zone resolved after medical treatment. Median longest axis of the ablation zone on post-ablation computed tomography was 38 mm (interquartile range, 30-40 mm). Histology showed coagulation necrosis of ablated tissue. Conclusions: Transbronchial MWA under augmented fluoroscopy guidance using a steerable sheath is feasible and accurate. © 2022 AME Publishing Company. All rights reserved. |
| Keywords: | lung neoplasms; ablation techniques; cone-beam computed tomography (cbct); augmented fluoroscopy; steerable sheath |
| Journal Title: | Translational Lung Cancer Research |
| Volume: | 11 |
| Issue: | 2 |
| ISSN: | 2218-6751 |
| Publisher: | Translational Lung Cancer Research |
| Date Published: | 2022-02-01 |
| Start Page: | 150 |
| End Page: | 164 |
| Language: | English |
| DOI: | 10.21037/tlcr-21-864 |
| PROVIDER: | scopus |
| PMCID: | PMC8902082 |
| PUBMED: | 35280317 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2022 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work