Ultrasound-guided percutaneous laser ablation of the thyroid gland in a swine model: Comparison of ablation parameters and ablation zone dimensions Journal Article
| Authors: | Ridouani, F.; Tuttle, R. M.; Ghosn, M.; Li, D.; Wong, R. J.; Fagin, J. A.; Monette, S.; Solomon, S. B.; Camacho, J. C. |
| Article Title: | Ultrasound-guided percutaneous laser ablation of the thyroid gland in a swine model: Comparison of ablation parameters and ablation zone dimensions |
| Abstract: | Background: To compare laser ablation (LA) zone dimensions at two predetermined energy parameters to cover a theoretical 10 mm zone + 2 mm margin in a thyroid swine model. Methods: Approval of the Institutional Animal Care and Use Committee was obtained. After hydrodissection, an ultrasound-guided LA (Elesta Echolaser X4 with Orblaze technology, 1064 nm) was performed in the periphery of the thyroid in 10 swine. Two cohorts were established to ablate a region of 10mm diameter with 2mm margin based on manufacturer’s ex vivo data (n= 5 at 3W/1400J and n= 5 at 3W/1800J). The ablation zone was measured on contrast-enhanced computed tomography (CT) and compared to the pathological specimen. Euthanasia was performed 48 hours following ablation. Results: All ablations in the 3W/1800J group achieved a diameter of 12 mm ± 1 mm in three dimensions. In the 3W/1400J group, 1 ablation reached 12 mm ± 1 mm in 2 dimensions and 4 ablations reached this size in one dimension. Maximum diameter was higher in the 3W/1800J compared to the 3W/1400J group, both on histology (1.46 cm ± 0.05 vs. 1.1 cm ± 0.0, p< 0.01) and CT (1.52 cm ± 0.04 vs. 1.18 cm ± 0.04, p< 0.01). Similar results were obtained regarding volumes, both on histology (1.12 mL ± 0.13 vs. 0.57 mL ± 0.06, p< 0.01) and CT (1.24 mL ± 0.13 vs. 0.59 mL ± 0.07, p< 0.01). Histology showed coagulation necrosis and correlated well with CT measurements. Conclusion: Optimal parameters to obtain a LA zone of 10 mm with 2 mm margin utilizing a single needle are 3W/1800J. © 2021, Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). |
| Keywords: | controlled study; histopathology; nonhuman; comparative study; animal tissue; computer assisted tomography; animal experiment; animal model; cohort analysis; ultrasound; radiology; contrast enhancement; iohexol; thyroid carcinoma; laser surgery; thyroid gland; laser; radiological parameters; thermal ablation; euthanasia; experimental pig; coagulative necrosis; article; interventional; papillary thyroid microcarcinoma; ablation zone dimension; ultrasound guided percutaneous laser ablation |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 44 |
| Issue: | 11 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Date Published: | 2021-11-01 |
| Start Page: | 1798 |
| End Page: | 1806 |
| Language: | English |
| DOI: | 10.1007/s00270-021-02915-0 |
| PUBMED: | 34254175 |
| PROVIDER: | scopus |
| PMCID: | PMC9578502 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2021 -- Source: Scopus |
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