Optimal detection pinhole for lowering speckle noise while maintaining adequate optical sectioning in confocal reflectance microscopes Journal Article
| Authors: | Glazowski, C.; Rajadhyaksha, M. |
| Article Title: | Optimal detection pinhole for lowering speckle noise while maintaining adequate optical sectioning in confocal reflectance microscopes |
| Abstract: | Coherent speckle influences the resulting image when narrow spectral line-width and single spatial mode illumination are used, though these are the same light-source properties that provide the best radiance-to-cost ratio. However, a suitable size of the detection pinhole can be chosen to maintain adequate optical sectioning while making the probability density of the speckle noise more normal and reducing its effect. The result is a qualitatively better image with improved contrast, which is easier to read. With theoretical statistics and experimental results, we show that the detection pinhole size is a fundamental parameter for designing imaging systems for use in turbid media. |
| Keywords: | methodology; sensitivity and specificity; reproducibility; reproducibility of results; cytology; confocal microscopy; image interpretation, computer-assisted; microscopy, confocal; signal noise ratio; algorithms; skin; algorithm; computer assisted diagnosis; image enhancement; artifact; artifacts; photometry; signal-to-noise ratio; nephelometry and turbidimetry |
| Journal Title: | Journal of Biomedical Optics |
| Volume: | 17 |
| Issue: | 8 |
| ISSN: | 1083-3668 |
| Publisher: | SPIE |
| Date Published: | 2012-01-01 |
| Start Page: | 085001 |
| Language: | English |
| PUBMED: | 23224184 |
| PROVIDER: | scopus |
| PMCID: | PMC3412991 |
| DOI: | 10.1117/1.jbo.17.8.085001 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 April 2013" - "Source: Scopus" |
