Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia Journal Article
| Authors: | Baljevic, M.; Abdel-Wahab, O.; Rampal, R.; Maslak, P. G.; Klimek, V. M.; Rosenblat, T. L.; Douer, D.; Levine, R. L.; Tallman, M. S. |
| Article Title: | Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia |
| Abstract: | Translocation t(11;17) is a well-recognized variant of acute promyelocytic leukemia (APL) and has also been identified in patients with mixed-lineage leukemia (MLL) non-APL acute myeloid leukemia. Here, we describe two patients bearing translocation t(11;17) presenting with a clinical diagnosis of de novo myelodysplastic syndrome (MDS): the first with sole karyotypic abnormality 46,XY,t(11;17)(p11.2; p13) and the second where it represented one of the two karyotypic abnormalities 46,XX,del(5)(q13q33)46,XX,del(5)(q13q33),t(11;17) (q24;q23). Molecular characterization of both cases failed to identify fusion transcripts involving MLL or PLZF-RARA and no collaborating somatic mutations commonly found among MDS patients were seen in either case, suggesting the presence of an as yet unidentified oncogenic fusion protein. Copyright © 2012 S. Karger AG, Basel. |
| Keywords: | adult; middle aged; leukemia, myeloid, acute; case report; neutrophil count; bone marrow; thrombocytopenia; creatinine; hemoglobin; creatinine blood level; hemoglobin blood level; urea nitrogen blood level; leukemia, promyelocytic, acute; myelodysplastic syndrome; promyelocytic leukemia; thrombocyte count; chromosome translocation; translocation, genetic; mean corpuscular volume; pancytopenia; leukocyte count; karyotyping; chromosomes, human, pair 11; metaphase; myelodysplastic syndromes; chromosomes, human, pair 17; karyotype 46,xx; 17); translocation t(11; chromosome 11 translocation; chromosome 17 translocation |
| Journal Title: | Acta Haematologica |
| Volume: | 129 |
| Issue: | 1 |
| ISSN: | 0001-5792 |
| Publisher: | S. Karger AG |
| Date Published: | 2013-01-01 |
| Start Page: | 48 |
| End Page: | 54 |
| Language: | English |
| DOI: | 10.1159/000342493 |
| PUBMED: | 23147462 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 26 March 2013" - "CODEN: ACHAA" - "Source: Scopus" |
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