Endocrine complications in long-term survivors of childhood cancers Journal Article
| Authors: | Chemaitilly, W.; Sklar, C. A. |
| Article Title: | Endocrine complications in long-term survivors of childhood cancers |
| Abstract: | Endocrine disturbances are among the most frequently reported complications in childhood cancer survivors, affecting between 20 and 50% of individuals who survive into adulthood. Most endocrine complications are the result of prior cancer treatments, especially radiotherapy. The objective of the present review is to discuss the main endocrine complications observed in this population, including disorders of the hypothalamic - pituitary axis, disorders of pubertal development, thyroid dysfunction, gonadal dysfunction, decreased bone mineral density, obesity, and alterations in glucose metabolism with a special focus on recent findings reported from the Childhood Cancer Survivor Study. © 2010 Society for Endocrinology. |
| Keywords: | adult; child; fracture; busulfan; prednisone; review; doxorubicin; side effect; pathophysiology; cancer radiotherapy; methotrexate; neoplasm; neoplasms; dacarbazine; obesity; cyclophosphamide; melphalan; vincristine; cancer therapy; chlormethine; ifosfamide; procarbazine; thiotepa; vinblastine; bone density; childhood cancer; gonad dysfunction; growth hormone deficiency; hodgkin disease; hypothalamus hypophysis system; ovary insufficiency; precocious puberty; skull irradiation; survivor; cancer survivor; survivors; bleomycin; glucocorticoid; osteoporosis; hyperthyroidism; hypothyroidism; endocrine disease; bone dysplasia; male infertility; endocrine system; osteopenia; endocrine system diseases; corticotropin deficiency; glucose metabolism; hyperprolactinemia; hypogonadotropic hypogonadism; spermatogenesis; testis injury; thyroid disease |
| Journal Title: | Endocrine-Related Cancer |
| Volume: | 17 |
| Issue: | 3 |
| ISSN: | 1351-0088 |
| Publisher: | Bioscientifica Ltd |
| Date Published: | 2010-06-03 |
| Start Page: | R141 |
| End Page: | R159 |
| Language: | English |
| DOI: | 10.1677/erc-10-0002 |
| PUBMED: | 20453080 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: ERCAE" - "Source: Scopus" |
