Endocrine late effects in childhood cancer survivors Journal Article


Authors: Chemaitilly, W.; Cohen, L. E.; Mostoufi-Moab, S.; Patterson, B. C.; Simmons, J. H.; Meacham, L. R.; van Santen, H. M.; Sklar, C. A.
Article Title: Endocrine late effects in childhood cancer survivors
Abstract: Endocrine complications are highly prevalent in childhood cancer survivors. Approximately 50% of survivors will experience at least one hormonal disorder over the course of their lives. Endocrine complications often are observed in survivors previously treated with radiation to the head, neck, or pelvis. We provide an overview the most common endocrine late effects seen in survivors, including hypothalamic-pituitary dysfunction, primary thyroid dysfunction, obesity, diabetes mellitus, metabolic syndrome, and decreased bone mineral density. Primary gonadal injury is discussed elsewhere in this series. Given a variable latency interval, a systematic approach where individuals are periodically screened on the basis of their risk factors can help to improve health outcomes by prompt diagnosis and treatment of evolving endocrinopathies. These recommendations must be revised in the future given changes and improvements in cancer treatment over time. © 2018 by American Society of Clinical Oncology
Journal Title: Journal of Clinical Oncology
Volume: 36
Issue: 21
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2018-07-20
Start Page: 2153
End Page: 2159
Language: English
DOI: 10.1200/jco.2017.76.3268
PROVIDER: scopus
PUBMED: 29874130
DOI/URL:
Notes: Review -- Export Date: 1 August 2018 -- Source: Scopus
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MSK Authors
  1. Charles A Sklar
    264 Sklar