Endocrine health in childhood cancer survivors Review
| Authors: | van Santen, H. M.; Chemaitilly, W.; Meacham, L. R.; Tonorezos, E. S.; Mostoufi-Moab, S. |
| Review Title: | Endocrine health in childhood cancer survivors |
| Abstract: | Endocrine late effects, including reproductive disorders and secondary thyroid cancer, have been reported in up to 50 %childhood cancer survivors (CCS) more than 5 years after treatment. Most endocrine disorders are amenable to treatment; awareness of symptoms is therefore of great importance. Recognition of these symptoms may be delayed however because many are nonspecific. Timely treatment of endocrine disorders improves quality of life in CCS and prevents possible consequences, such as short stature, bone and cardiovascular disorders, and depression. At-risk CCS must therefore be regularly and systematically monitored. This article provides a summary of the most commonly reported endocrine late effects in CCS. © 2020 The Author(s) |
| Keywords: | cancer surgery; busulfan; prednisone; review; sorafenib; interferon; sunitinib; risk benefit analysis; side effect; cancer radiotherapy; cytarabine; imatinib; carboplatin; dacarbazine; ipilimumab; etoposide; obesity; dexamethasone; melphalan; carmustine; chlormethine; lomustine; procarbazine; bone density; childhood cancer; growth hormone deficiency; hypothalamus hypophysis system; precocious puberty; short stature; late effects; protein tyrosine kinase inhibitor; radiation effects; radiation dose fractionation; surgical risk; glucocorticoid; metabolic syndrome x; (3 iodobenzyl)guanidine i 131; gonadorelin agonist; hydrocortisone; second cancer; hypothyroidism; levothyroxine; sex hormone; retinoic acid; endocrine disease; growth retardation; growth disorder; bone dysplasia; gonadotropin derivative; metabolic syndrome; bone health; hyperprolactinemia; thyroid disease; scoliosis; hypophysitis; thyroiditis; childhood cancer survivor; desmopressin; diabetes insipidus; autoimmune thyroiditis; hypophysis disease; central diabetes insipidus; hormone deficiency; thyrotoxicosis; premature ovarian failure; autoimmune hypophysitis; recombinant growth hormone; human; checkpoint kinase inhibitor; central precocious puberty; secondary thyroid cancer; adrenocorticotrophic hormone deficiency; follicle stimulating hormone deficiency; luteinizing hormone deficiency; slipped capital femoral epiphysis; thyroid stimulating hormone deficiency |
| Journal Title: | Pediatric Clinics of North America |
| Volume: | 67 |
| Issue: | 6 |
| ISSN: | 0031-3955 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2020-12-01 |
| Start Page: | 1171 |
| End Page: | 1186 |
| Language: | English |
| DOI: | 10.1016/j.pcl.2020.08.002 |
| PUBMED: | 33131540 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 December 2020 -- Source: Scopus |
