Pediatric and adolescent synovial sarcoma: Multivariate analysis of prognostic factors and survival outcomes Journal Article

  


Authors: Stanelle, E. J.; Christison-Lagay, E. R.; Healey, J. H.; Singer, S.; Meyers, P. A.; La Quaglia, M. P.
Article Title: Pediatric and adolescent synovial sarcoma: Multivariate analysis of prognostic factors and survival outcomes
Abstract: Purpose: Treatment of synovial sarcoma (SS) is challenging because of its unpredictable clinical behavior. We reviewed our institutional experience with pediatric SS to identify prognostic indicators and survival outcomes. Methods: We retrospectively reviewed all pediatric/adolescent patients (age <22 years) with confirmed SS treated from 1970 to 2010. Patient and clinical characteristics were evaluated for prognostic significance and survival outcomes. Results: We identified 111 patients. The median age was 15.4 years. Sixty-seven tumors (60 %) were monophasic, 42 (38 %) were biphasic, and 2 (2 %) were of unknown histology. Median follow-up was 5.3 years (range 0.8-36.8 years), 5-year overall survival (OS) was 73 %, and 10-year OS was 65 %. Greater tumor size (stratified as ≤5 cm, >5 cm, or ≥10 cm) (P = 0.001) and depth (P = 0.03) correlated with decreased OS. Primary tumor location in the upper extremity correlated with increased OS when compared with lower-extremity and central lesions (P = 0.05). Bone and/or neurovascular invasion negatively impacted survival (P = 0.02). Multivariate analysis revealed that tumor size (trichotomized) was the dominant and sole factor in discriminating survival risk. Neither radiotherapy nor chemotherapy correlated with improved 5-year survival. Conclusions: Tumor size, depth, invasion, and primary location affect survival in pediatric SS. The role of radiotherapy and chemotherapy for SS warrants future study. © 2012 Society of Surgical Oncology.
Keywords: adolescent; adult; cancer survival; child; preschool child; school child; cancer surgery; major clinical study; overall survival; review; cancer recurrence; salvage therapy; doxorubicin; cancer adjuvant therapy; cancer radiotherapy; follow up; etoposide; retrospective study; ifosfamide; cancer invasion; cancer size; multivariate analysis; synovial sarcoma; leg; arm; cancer prognosis
Journal Title: Annals of Surgical Oncology
Volume: 20
Issue: 1
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2013-01-01
Start Page: 73
End Page: 79
Language: English
DOI: 10.1245/s10434-012-2587-9
PROVIDER: scopus
PUBMED: 22878620
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84871735622&partnerID=40&md5=3a66d8cc273380dd583bbfb47af94b1d
Notes: --- - "Export Date: 1 February 2013" - "CODEN: ASONF" - "Source: Scopus"
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MSK Authors
  1. Michael P La Quaglia
    413 La Quaglia
  2. Samuel Singer
    338 Singer
  3. Paul Meyers
    311 Meyers
  4. John H Healey
    553 Healey
  5. Emily Rachel Christison-Lagay
    6 Christison-Lagay
  6. Eric Jon Stanelle
    6 Stanelle
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