Prognostic factors and survival in pediatric and adolescent liposarcoma Journal Article

   


Authors: Stanelle, E. J.; Christison-Lagay, E. R.; Sidebotham, E. L.; Singer, S.; Antonescu, C. R.; Meyers, P. A.; La Quaglia, M. P.
Article Title: Prognostic factors and survival in pediatric and adolescent liposarcoma
Abstract: Purpose. Liposarcoma is extremely rare in the pediatric population. To identify prognostic factors and determine treatment outcomes, we reviewed our institutional experience with pediatric liposarcoma. Methods. We retrospectively reviewed all pediatric patients (age 22 years) with confirmed liposarcoma treated at Memorial Sloan-Kettering Cancer Center. Histologic subtype, tumor location, margin status, recurrence, and adjuvant therapy were analyzed and correlated with overall survival. Results. Thirty-four patients (56 male) with a median age of 18.1 years were identified. Twenty-two (65) had peripheral tumors and 12 (35) had centrally located tumors. Histologically, 29 (85) tumors were low grade, and 5 (15) were high grade pleomorphic. Eleven (32) had recurrent disease, 9 patients with central tumors and 2 patients with peripheral lesions. Eight deaths occurred, all in patients with central disease. Five-year overall survival was 78, with a median follow-up time of 5.4 years (range, 0.330.3 years). Tumor grade (P =.003), histologic subtype (P =.01), and primary location (P .001) all correlated with survival, as did stage (P .001) and margin status (P =.001). Conclusions. Central location of the primary tumor, high tumor grade, and positive surgical margins are strongly correlated with poor survival in pediatric patients with liposarcoma. © 2012 Eric J. Stanelle et al.
Journal Title: Sarcoma
Volume: 2012
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2012-01-01
Start Page: 870910
Language: English
DOI: 10.1155/2012/870910
PROVIDER: scopus
PMCID: PMC3443598
PUBMED: 22991488
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84867304953&partnerID=40&md5=9c03357513e3cf8e1ee89d4b23b59ccd
Notes: --- - "Export Date: 2 November 2012" - "CODEN: SARCF" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Michael P La Quaglia
    411 La Quaglia
  2. Cristina R Antonescu
    895 Antonescu
  3. Emma Louise Sidebotham
    4 Sidebotham
  4. Samuel Singer
    337 Singer
  5. Paul Meyers
    311 Meyers
  6. Emily Rachel Christison-Lagay
    6 Christison-Lagay
  7. Eric Jon Stanelle
    6 Stanelle
Related MSK Work