Pulmonary metastasectomy in pediatric/adolescent patients with synovial sarcoma: An institutional review Journal Article

  


Authors: Stanelle, E. J.; Christison-Lagay, E. R.; Wolden, S. L.; Meyers, P. A.; La Quaglia, M. P.
Article Title: Pulmonary metastasectomy in pediatric/adolescent patients with synovial sarcoma: An institutional review
Abstract: Purpose: Synovial sarcoma (SS) often metastasizes to the lung; however, the indications for and outcomes of pulmonary metastasectomy have not been evaluated in pediatric/adolescent patients. Methods: The records of pediatric patients (age < 22 years) with pathologically confirmed SS and pulmonary metastasis treated between June 1971 and May 2011 at our institution were retrospectively reviewed for the number and type of surgical metastasectomies, tumor characteristics, and survival outcomes. Results: Forty-one patients (mean age: 15.9 years) were identified and 31 (76%) underwent at least one metastasectomy. Seventy-two resections (range, 1-8/patient) were performed. Two- and 5-year survival rates after metastasis diagnosis were 65% and 24% for patients who underwent metastasectomy. Patients who did not undergo a metastasectomy survived no more than 2 years from the diagnosis of pulmonary disease (P < 0.001). Longer time to progression after primary tumor resection (> 1 year) and complete resection of pulmonary disease correlated with greater OS (P = 0.02 and P < 0.001, respectively). Palliative debulking did not improve OS. Survival was unaffected by tumor histological subtype, bilateral pulmonary disease, number of surgical resections, or number and size of resected metastatic lesions. Conclusion: Pulmonary metastasectomy may be associated with improved survival in pediatric/adolescent patients with SS and pulmonary metastases if complete resection is achieved. © 2013 Elsevier Inc. All rights reserved.
Keywords: survival; adolescent; adult; cancer chemotherapy; cancer survival; child; clinical article; human tissue; preschool child; school child; treatment outcome; child, preschool; survival rate; retrospective studies; young adult; overall survival; review; doxorubicin; cancer growth; bone metastasis; cancer adjuvant therapy; outcome assessment; cancer palliative therapy; cytoreductive surgery; lung lobectomy; lung resection; thoracotomy; lung neoplasms; surgical approach; medical record review; histology; ifosfamide; pediatric; survival time; lung metastasis; infant; cancer size; reoperation; soft tissue sarcoma; synovial sarcoma; sarcoma, synovial; sternotomy; video assisted thoracoscopic surgery; metastasectomy; metastatic; soft tissue metastasis; wedge resection; metastasis resection; pulmonary
Journal Title: Journal of Pediatric Surgery
Volume: 48
Issue: 4
ISSN: 0022-3468
Publisher: W.B. Saunders Co-Elsevier Inc.  
Date Published: 2013-04-01
Start Page: 757
End Page: 763
Language: English
PROVIDER: scopus
PUBMED: 23583130
DOI: 10.1016/j.jpedsurg.2012.09.042
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84876237877&partnerID=40&md5=cad8213677fcc8784dbd8f0ac507a0e2
Notes: --- - "Export Date: 1 May 2013" - "CODEN: JPDSA" - ":doi 10.1016/j.jpedsurg.2012.09.042" - "Source: Scopus"
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MSK Authors
  1. Michael P La Quaglia
    411 La Quaglia
  2. Suzanne L Wolden
    560 Wolden
  3. Paul Meyers
    311 Meyers
  4. Emily Rachel Christison-Lagay
    6 Christison-Lagay
  5. Eric Jon Stanelle
    6 Stanelle
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