Irreversible electroporation adjacent to the rectum: Evaluation of pathological effects in a pig model Journal Article
| Authors: | Schoellnast, H.; Monette, S.; Ezell, P. C.; Single, G.; Maybody, M.; Weiser, M. R.; Fong, Y.; Solomon, S. B. |
| Article Title: | Irreversible electroporation adjacent to the rectum: Evaluation of pathological effects in a pig model |
| Abstract: | Purpose: To evaluate the effects of irreversible electroporation (IRE) on the rectum wall after IRE applied adjacent to the rectum. Material and Methods: CT-guided IRE adjacent to the rectum wall was performed in 11 pigs; a total of 44 lesions were created. In five pigs, ablations were performed without a water-filled endorectal coil (group A); in six pigs, ablation was performed with the coil to avoid displacement of the rectum wall (group B). The pigs were killed after 7-15 days and the rectums were harvested for pathological evaluation. Results: There was no evidence of perforation on gross postmortem examination. Perirectal muscle lesions were observed in 18 of 20 ablations in group A and in 21 of 24 ablations in group B. Inflammation and fibrosis of the muscularis propria was observed in ten of 18 lesions in group A and in ten of 21 lesions in group B. In group A, findings were limited to the external layer of the muscularis propria except for one lesion; in group B, findings were transmural in all cases. Transmural necrosis with marked suppurative mucosal inflammation was observed in seven of 21 lesions in group B and in no lesion in group A. Conclusion: IRE-ablation adjacent to the rectum may be uneventful if the rectum wall is mobile and able to contract. IRE-ablation of the rectum may be harmful if the rectum wall is fixed adjacent to the IRE-probe. © 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). |
| Keywords: | rectum; ablation; irreversible electroporation; ire; non-thermal ablation |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 36 |
| Issue: | 1 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Date Published: | 2013-02-01 |
| Start Page: | 213 |
| End Page: | 220 |
| Language: | English |
| DOI: | 10.1007/s00270-012-0393-1 |
| PROVIDER: | scopus |
| PUBMED: | 22562481 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2013" - "CODEN: CARAD" - "Source: Scopus" |
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