Evaluation of an endorectal electrode for performing focused irreversible electroporation ablations in the swine rectum Journal Article

Authors: Srimathveeravalli, G.; Wimmer, T.; Monette, S.; Gutta, N. B.; Ezell, P. C.; Maybody, M.; Weiser, M. R.; Solomon, S. B.
Article Title: Evaluation of an endorectal electrode for performing focused irreversible electroporation ablations in the swine rectum
Abstract: Purpose To study the feasibility of a novel endorectal electrode for the creation of focal ablations of the rectal wall with the use of irreversible electroporation (IRE). Materials and Methods A monopolar electrode with a grounding pad (10 ablations in five pigs) and a bipolar electrode (two ablations in one pig) were evaluated in healthy swine rectum. A two-dimensional model of the electrode in the rectum was created and used to solve the Laplace equation to determine field strength. Simulation was used to identify treatment settings for superficial ablation (mucosal layers) or transmural ablation of rectal wall. Animals were euthanized within 4 hours after treatment. Results Treatment was successfully completed without treatment-related complications. Eleven of 12 lesions were successfully located and extracted for pathologic analysis. All lesions were characterized by necrotic cell death with mild inflammation and hyperemia, with a sharp demarcation between ablated and adjacent normal tissue. Depth of lesions corresponded with numeric simulation. Histologic analysis and measurements indicated that lesion creation with the superficial treatment setting resulted in ablation of mucosal and submucosal layers with superficial or no injury to the muscularis propria (9.97 mm ± 0.31 length, 3.3 mm ± 2.92 depth), and that lesion creation with the transmural treatment setting resulted in full-thickness ablation (12.43 mm ± 3.85 length, 4.97 mm ± 2.89 depth) of the rectal wall. Conclusions An endorectal electrode can be used to deliver IRE and create limited focal ablations in the rectal wall. Treatment parameters can be determined through numeric modeling to control the depth of penetration of ablation. © 2013 SIR.
Keywords: controlled study; histopathology; nonhuman; animal tissue; cell death; edema; computer assisted tomography; animal experiment; inflammation; simulation; feasibility study; contrast enhancement; collagen; electroporation; ablation therapy; rectum hemorrhage; electrode; hyperemia; rectum injury; irreversible electroporation; experimental pig; muscle contraction; animal euthanasia; endorectal electrode; muscle thickness
Journal Title: Journal of Vascular and Interventional Radiology
Volume: 24
Issue: 8
ISSN: 1051-0443
Publisher: Elsevier Science, Inc.  
Date Published: 2013-08-01
Start Page: 1249
End Page: 1256
Language: English
DOI: 10.1016/j.jvir.2013.04.025
PROVIDER: scopus
PUBMED: 23796856
Notes: --- - "Export Date: 4 September 2013" - "CODEN: JVIRE" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Majid Maybody
    72 Maybody
  2. Martin R Weiser
    346 Weiser
  3. Stephen Solomon
    267 Solomon
  4. Sebastien Monette
    77 Monette
  5. Paula Cherie Ezell
    19 Ezell
  6. Narendra Babu Gutta
    7 Gutta