Optimizing therapy for transplant-eligible patients with newly diagnosed multiple myeloma Journal Article
| Authors: | Moreau, P.; Giralt, S. A. |
| Article Title: | Optimizing therapy for transplant-eligible patients with newly diagnosed multiple myeloma |
| Abstract: | High-dose chemotherapy and autologous stem-cell transplantation (HDT-ASCT) is standard therapy for younger patients with multiple myeloma (MM) who are physically fit enough to undergo the treatment. Nevertheless, MM remains incurable and strategies to prevent or delay relapse after HDT-ASCT are needed. A continuous therapy approach using maintenance therapy may provide sustained control of minimal residual disease after HDT-ASCT. Alternatively, extending treatment with novel induction regimens may delay the need for HDT-ASCT. Although there is some clinical evidence to support the use of these strategies, their efficacy has not been proven definitively in clinical trials; ongoing studies should help determine their merit in transplant-eligible patients with MM. © 2012 Elsevier B.V.. |
| Keywords: | cancer survival; overall survival; lenalidomide; prednisone; thalidomide; drug tolerability; neutropenia; cancer recurrence; salvage therapy; doxorubicin; interferon; placebo; cancer combination chemotherapy; dose response; drug efficacy; drug safety; drug withdrawal; patient selection; risk benefit analysis; treatment duration; treatment planning; unspecified side effect; combined modality therapy; drug megadose; antineoplastic agent; evidence based medicine; imatinib; progression free survival; bortezomib; multiple cycle treatment; multiple myeloma; bone marrow suppression; antineoplastic combined chemotherapy protocols; peripheral neuropathy; calibration; dexamethasone; melphalan; vincristine; autologous stem cell transplantation; stem cell transplantation; drug effect; dose-response relationship, drug; chronic myeloid leukemia; minimal residual disease; clinical effectiveness; cancer control; corticosteroid; age of onset; transplantation, autologous; graft recipient; induction chemotherapy; stem-cell transplantation; induction; maintenance; maintenance chemotherapy; continuous therapy; transplant-eligible |
| Journal Title: | Leukemia Research |
| Volume: | 36 |
| Issue: | SUPPL.1 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2012-11-01 |
| Start Page: | S13 |
| End Page: | S18 |
| Language: | English |
| DOI: | 10.1016/s0145-2126(12)70004-8 |
| PROVIDER: | scopus |
| PUBMED: | 23176719 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 January 2013" - "CODEN: LERED" - "Source: Scopus" |
