Stem cell transplantation in Hodgkin lymphoma Journal Article


Authors: Reddy, N. M.; Perales, M. A.
Article Title: Stem cell transplantation in Hodgkin lymphoma
Abstract: Patients with Hodgkin lymphoma (HL) who relapse following effective front-line therapy are offered salvage second-line chemotherapy regimens followed by high-dose therapy and autologous stem cell transplantation (HDT/ASCT). Randomized studies comparing HDT/ASCT with conventional chemotherapy in patients with relapsed refractory HL have shown significant improvement in progression-free survival and freedom from treatment failure but were not powered to show improvements in overall survival. For patients who relapse after salvage HDT/ASCT, novel therapies exist as a bridge to allogeneic SCT. In this article, we review indications and results of autologous and allogeneic SCT in HL.
Keywords: treatment outcome; treatment failure; histone deacetylase inhibitor; allogeneic stem cell transplantation; review; cancer recurrence; salvage therapy; positron emission tomography; follow up; treatment indication; lung toxicity; bendamustine; autologous stem cell transplantation; stem cell transplantation; radiation injury; hodgkin disease; myelodysplastic syndrome; cardiotoxicity; protein farnesyltransferase inhibitor; reduced intensity conditioning; long term care; allogeneic hematopoietic stem cell transplantation; immunomodulating agent; endocrine disease; hodgkin lymphoma; cancer prognosis; brentuximab vedotin; human; donor-lymphocyte infusion; brentuximab-vedotin
Journal Title: Hematology/Oncology Clinics of North America
Volume: 28
Issue: 6
ISSN: 0889-8588
Publisher: Elsevier Inc.  
Date Published: 2014-12-01
Start Page: 1097
End Page: 1112
Language: English
DOI: 10.1016/j.hoc.2014.08.011
PROVIDER: scopus
PUBMED: 25459181
DOI/URL:
Notes: Export Date: 2 January 2015 -- Source: Scopus
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  1. Miguel-Angel Perales
    918 Perales