Authors: | Reddy, N. M.; Perales, M. A. |
Article Title: | Stem cell transplantation in Hodgkin lymphoma |
Abstract: | Patients with Hodgkin lymphoma (HL) who relapse following effective front-line therapy are offered salvage second-line chemotherapy regimens followed by high-dose therapy and autologous stem cell transplantation (HDT/ASCT). Randomized studies comparing HDT/ASCT with conventional chemotherapy in patients with relapsed refractory HL have shown significant improvement in progression-free survival and freedom from treatment failure but were not powered to show improvements in overall survival. For patients who relapse after salvage HDT/ASCT, novel therapies exist as a bridge to allogeneic SCT. In this article, we review indications and results of autologous and allogeneic SCT in HL. |
Keywords: | treatment outcome; treatment failure; histone deacetylase inhibitor; allogeneic stem cell transplantation; review; cancer recurrence; salvage therapy; positron emission tomography; follow up; treatment indication; lung toxicity; bendamustine; autologous stem cell transplantation; stem cell transplantation; radiation injury; hodgkin disease; myelodysplastic syndrome; cardiotoxicity; protein farnesyltransferase inhibitor; reduced intensity conditioning; long term care; allogeneic hematopoietic stem cell transplantation; immunomodulating agent; endocrine disease; hodgkin lymphoma; cancer prognosis; brentuximab vedotin; human; donor-lymphocyte infusion; brentuximab-vedotin |
Journal Title: | Hematology/Oncology Clinics of North America |
Volume: | 28 |
Issue: | 6 |
ISSN: | 0889-8588 |
Publisher: | Elsevier Inc. |
Date Published: | 2014-12-01 |
Start Page: | 1097 |
End Page: | 1112 |
Language: | English |
DOI: | 10.1016/j.hoc.2014.08.011 |
PROVIDER: | scopus |
PUBMED: | 25459181 |
DOI/URL: | |
Notes: | Export Date: 2 January 2015 -- Source: Scopus |