Extraneural ependymoma: Distant bone, lung, liver, and lymph node metastases following bevacizumab Journal Article


Authors: Fischer, C.; Haque, S. S.; Huse, J. T.; Blochin, E.; Souweidane, M. M.; Lis, E.; Khakoo, Y.
Article Title: Extraneural ependymoma: Distant bone, lung, liver, and lymph node metastases following bevacizumab
Abstract: Extraneural metastases of ependymoma are rare, and have been reported in the lungs, lymph nodes, pleura, mediastinum, liver, diaphragmatic muscle, and bone. We report a case of anaplastic ependymoma with distant metastases to the vertebral bones, lungs, liver, and lymph nodes following treatment with bevacizumab. Recent research has hypothesized that angiogenic tumors may develop means of resistance to antiangiogenic therapies, and some evidence suggests potential for antiangiogenic therapies to promote additional means for cancer spread. Nevertheless, antiangiogenic therapies continue to demonstrate potential as potent therapies for the treatment of many cancers, and should continue to be researched for future uses. © 2012 Wiley Periodicals, Inc.
Keywords: cancer chemotherapy; child; human tissue; preschool child; case report; bevacizumab; drug withdrawal; bone metastasis; nuclear magnetic resonance imaging; lymph node metastasis; computer assisted tomography; angiogenesis; oncology; distant metastasis; irinotecan; liver metastasis; lung metastasis; tamoxifen; ependymoma; headache; antibodies; developmental disorder; drug substitution; brain biopsy; hemiparesis; rare disease; brain tumors; focal epilepsy; macrocephaly
Journal Title: Pediatric Blood and Cancer
Volume: 60
Issue: 1
ISSN: 1545-5009
Publisher: Wiley Periodicals, Inc  
Date Published: 2013-01-01
Start Page: 143
End Page: 145
Language: English
DOI: 10.1002/pbc.24268
PROVIDER: scopus
PUBMED: 22976578
DOI/URL:
Notes: --- - "Export Date: 2 January 2013" - "CODEN: PBCEA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Eric Lis
    102 Lis
  2. Yasmin Khakoo
    99 Khakoo
  3. Sofia S Haque
    72 Haque
  4. Cheryl Melissa Fischer
    10 Fischer
  5. Jason T Huse
    127 Huse