Therapeutic Sentinel Lymph Node Imaging Journal Article

  


Authors: Kachala, S. S.; Servais, E. L.; Park, B. J.; Rusch, V. W.; Adusumilli, P. S.
Article Title: Therapeutic Sentinel Lymph Node Imaging
Abstract: Improving existing means of sentinel lymph node identification in non-small cell lung cancer will allow for molecular detection of occult micrometastases that may cause recurrence in early stage non-small cell lung cancer. Furthermore, targeted application of chemical and biological cytotoxic agents can potentially improve outcomes in patients with lymph node (LN) metastases. "Therapeutic Sentinel Lymph Node Imaging" incorporates these modalities into a single agent thereby identifying which LNs harbor tumor cells and simultaneously eradicating metastatic disease. In this review, we summarize the novel preclinical agents for identification and treatment of tumor bearing LNs and discuss their potential for clinical translation. © 2009 Elsevier Inc. All rights reserved.
Keywords: cancer chemotherapy; treatment outcome; unclassified drug; clinical trial; cisplatin; doxorubicin; liver cell carcinoma; nonhuman; patient selection; paclitaxel; lymph node metastasis; antineoplastic agent; lymph nodes; lymphatic metastasis; neoplasm staging; sentinel lymph node mapping; sentinel lymph node; sentinel lymph node biopsy; animals; melanoma; breast cancer; carcinoma, non-small-cell lung; lung neoplasms; drug dosage form comparison; lung cancer; diagnostic imaging; viral gene delivery system; drug mechanism; mitoxantrone; predictive value of tests; oncolytic herpes virus; micrometastasis; oncolytic virotherapy; pleura mesothelioma; bleomycin; rectum cancer; nv 1020; epidermal growth factor receptor antibody; macrogol; quantum dot; fluorescent imaging; targeted; liposome; nv1023; nv1066; obp 401; plasmid vector; polyglactin; drug delivery system; lymphatic system examination; particle size
Journal Title: Seminars in Thoracic and Cardiovascular Surgery
Volume: 21
Issue: 4
ISSN: 1043-0679
Publisher: Elsevier Inc.  
Date Published: 2009-12-01
Start Page: 327
End Page: 338
Language: English
DOI: 10.1053/j.semtcvs.2009.11.002
PUBMED: 20226346
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77649246880&partnerID=40&md5=015d1f424cd5ed233b460527a6357bcf
Notes: --- - "Export Date: 30 November 2010" - "CODEN: STCSC" - "Source: Scopus"
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MSK Authors
  1. Valerie W Rusch
    865 Rusch
  2. Elliot Louis Servais
    17 Servais
  3. Bernard J Park
    263 Park
  4. Stefan S Kachala
    10 Kachala
  5. Prasad S Adusumilli
    496 Adusumilli
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