| Abstract: |
Ependymomas, glial neoplasms usually arising in the posterior fossa or spinal cord, rarely metastasize outside the central nervous system. We have reviewed all 81 ependymomas evaluated at MSKCC between 1956-1989. Five (6.2%) had extraneural metastases (ENM). The primary tumor was in spinal cord in 3 patients and the cerebral hemisphere in 2. Two tumors were histologically anaplastic; 3 were histologically benign. The 5 patients were 3, 3, 3.5, 16 and 37 years old. Time from initial diagnosis to development of ENM was 0, 15, 35, 40, and 288 months. At the time of ENM the primary tumor was progressing in 4/5 patients. Prior therapy had included resection plus radiation therapy (RT) (1), RT plus chemotherapy (1), resection plus RT plus chemotherapy (2). One patient had not received prior therapy because ENM were present at diagnosis. The sites of ENM included lung and thoracic lymph nodes (2), pleura and peritoneum (2), and liver (1). Both patients with peritoneal ENM had had ventriculoperitoneal shunts. ENM did not correlate with histologic grade, age, or degree of surgical resection. When patients with ependymoma develop signs or symptoms of systemic disease such as abdominal pain, cough, or adenopathy, ENM should be considered. © 1992 Kluwer Academic Publishers. |
| Keywords: |
adolescent; adult; child; clinical article; controlled study; human tissue; child, preschool; retrospective studies; case report; cisplatin; combined modality therapy; methotrexate; glioma; brain neoplasms; carboplatin; metastasis; peritoneal neoplasms; etoposide; lung neoplasms; vincristine; lomustine; ependymoma; metastases; neoplasms, multiple primary; soft tissue neoplasms; neoplasm seeding; spinal cord neoplasms; omentum; human; male; female; article; cerebrospinal fluid shunts; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; extraneural
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