Removal of polysialic acid triggers dispersion of subventricularly derived neuroblasts into surrounding CNS tissues Journal Article
| Authors: | Battista, D.; Rutishauser, U. |
| Article Title: | Removal of polysialic acid triggers dispersion of subventricularly derived neuroblasts into surrounding CNS tissues |
| Abstract: | Cells generated in the subventricular zone give rise to neuroblasts that migrate to the olfactory bulb (OB) along the rostral migratory stream (RMS). The polysialylated form of neural cell adhesion molecule (PSA-NCAM) is expressed by these cells, and has been shown to both promote their migration and suppress differentiation induced by NCAM. In the present study, enzymatic removal of PSA from these neuroblasts using PSA-specific endoneuraminidase has been found not only to disrupt the tangential migration and cellular organization of the RMS, but also to cause a massive dispersion of BrdU (5-bromo-2′-deoxyuridine)- labeled neuroblasts into surrounding brain regions, including cortex and striatum. These dispersed cells are capable of differentiation, some into mature neurons, and could potentially be of value in the repair of CNS injury. Although the removal of PSA by genetic deletion of NCAM also results in a smaller OB and a swollenRMS,the cells do not escape theRMSin large numbers. These findings suggest that the presence ofNCAMwithoutPSAplays a role in the dispersion process, possibly by inducing a new pattern of migration associated with NCAM-dependent differentiation. Copyright © 2010 the authors. |
| Keywords: | controlled study; nonhuman; mouse; animals; mice; mice, knockout; animal tissue; apoptosis; cell maturation; animal experiment; brain cortex; subventricular zone; cell differentiation; neurons; mice, inbred balb c; central nervous system; brain; polysialic acid; sialidase; cell migration; cell movement; stem cells; nerve cell differentiation; neurogenesis; brain region; neuroblast; corpus striatum; sialic acids; olfactory bulb; bromodeoxyuridine; nerve cell necrosis; cerebral ventricles; glycoside hydrolases; neural cell adhesion molecules |
| Journal Title: | The Journal of Neuroscience |
| Volume: | 30 |
| Issue: | 11 |
| ISSN: | 0270-6474 |
| Publisher: | Society for Neuroscience |
| Date Published: | 2010-03-17 |
| Start Page: | 3995 |
| End Page: | 4003 |
| Language: | English |
| DOI: | 10.1523/jneurosci.4382-09.2010 |
| PUBMED: | 20237270 |
| PROVIDER: | scopus |
| PMCID: | PMC6632263 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "CODEN: JNRSD" - "Source: Scopus" |
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