Roles, regulation, and mechanism of polysialic acid function during neural development Journal Article

  


Authors: Brusés, J. L.; Rutishauser, U.
Article Title: Roles, regulation, and mechanism of polysialic acid function during neural development
Abstract: The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) appeared during the evolution of vertebrates as a new mechanism for regulation of cell interactions. This large and abundant glycoprotein can exert steric effects at the cell surface that lead to the attenuation of cell-cell bonds mediated not only by NCAM but also a variety of other adhesion receptors. PSA-NCAM expression changes both as a result of developmental programs and physiological inputs. This global modulation of cell-cell attachment has been shown to facilitate cell migration, axon pathfinding and targeting, and plastic changes in the embryonic and adult nervous system. © 2001 Société française de biochimie et biologie moléculaire / Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
Keywords: review; animals; mice; protein targeting; embryo development; evolution; central nervous system; physiology; vertebrata; regulatory mechanism; motor neurons; nerve cell adhesion molecule; polysialic acid; nerve cell plasticity; sialyltransferase; sialyltransferases; cell migration; cell adhesion molecules; receptor; animals, newborn; polysaccharides; cell interaction; cell communication; nervous system development; vertebrate; vertebrates; glycoprotein; stereochemistry; sialic acids; neuronal plasticity; chick embryo; modulation; cell surface; neural cell adhesion molecules; cell interactions; neural development
Journal Title: Biochimie
Volume: 83
Issue: 7
ISSN: 0300-9084
Publisher: Editions Scientifiques Elsevier  
Date Published: 2001-07-01
Start Page: 635
End Page: 643
Language: English
DOI: 10.1016/s0300-9084(01)01293-7
PUBMED: 11522392
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0034856448&partnerID=40&md5=3d8385304d539dab9946635178f0c5eb
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Juan L Bruses
    15 Bruses
  2. Urs S Rutishauser
    70 Rutishauser
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