The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity Journal Article
| Authors: | Gómez-Climent, M. A.; Guirado, R.; Castillo-Gómez, E.; Varea, E.; Gutierrez-Mecinas, M.; Gilabert Juan, J.; García-Mompó, C.; Vidueira, S.; Sanchez-Mataredona, D.; Hernández, S.; Blasco-Ibáñez, J. M.; Crespo, C.; Rutishauser, U.; Schachner, M.; Nacher, J. |
| Article Title: | The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity |
| Abstract: | Principal neurons in the adult cerebral cortex undergo synaptic, dendritic, and spine remodeling in response to different stimuli, and several reports have demonstrated that the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) participates in these plastic processes. However, there is only limited information on the expression of this molecule on interneurons and on its role in the structural plasticity of these cells. We have found that PSA-NCAM is expressed in mature interneurons widely distributed in all the extension of the cerebral cortex and have excluded the expression of this molecule in most principal cells. Although PSA-NCAM expression is generally considered a marker of immature neurons, birth-dating analyses reveal that these interneurons do not have an adult or perinatal origin and that they are generated during embryonic development. PSA-NCAM expressing interneurons show reduced density of perisomatic and peridendritic puncta expressing different synaptic markers and receive less perisomatic synapses, when compared with interneurons lacking this molecule. Moreover, they have reduced dendritic arborization and spine density. These data indicate that PSA-NCAM expression is important for the connectivity of interneurons in the adult cerebral cortex and that its regulation may play an important role in the structural plasticity of inhibitory networks. © The Author 2010. Published by Oxford University Press. All rights reserved. |
| Keywords: | protein expression; unclassified drug; nonhuman; mouse; animals; animal tissue; embryo; brain cortex; cell differentiation; interneuron; interneurons; nerve cell adhesion molecule; nerve cell plasticity; rat; rats; cell density; cell shape; rats, sprague-dawley; cerebral cortex; neurogenesis; neural cell adhesion molecule l1; sialic acids; neuronal plasticity; neural pathways; dendrite remodeling; dendritic arborization; interneuron subtypes; ncam; neuronal structural plasticity; spine remodeling; polysialylated nerve cell adhesion molecule; dendritic spine; perikaryon; neural inhibition |
| Journal Title: | Cerebral Cortex |
| Volume: | 21 |
| Issue: | 5 |
| ISSN: | 1047-3211 |
| Publisher: | Oxford University Press |
| Date Published: | 2011-05-01 |
| Start Page: | 1028 |
| End Page: | 1041 |
| Language: | English |
| DOI: | 10.1093/cercor/bhq177 |
| PROVIDER: | scopus |
| PUBMED: | 20843898 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: CECOE" - "Source: Scopus" |
