Solving the convergence problem in the synthesis of triantennary N-glycan relevant to Prostate-Specific Membrane Antigen (PSMA) Journal Article

   


Authors: Walczak, M. A.; Danishefsky, S. J.
Article Title: Solving the convergence problem in the synthesis of triantennary N-glycan relevant to Prostate-Specific Membrane Antigen (PSMA)
Abstract: The first total synthesis of triantennary, fully sialylated N-glycan of complex type is described. Two strategies for installation of sialylated antennae are explored, and both approaches converge on a global glycosylation step that delivers the desired tetradecasaccharide in good yields. © 2012 American Chemical Society.
Keywords: unclassified drug; complex formation; prostate specific membrane antigen; chemistry; cancer vaccines; glycosylation; chemical structure; polysaccharides; synthesis; total synthesis; synthesis (chemical); carbohydrate; stereochemistry; glutamate carboxypeptidase ii; antigens, surface; chemical modification; pentasaccharide; deprotection reaction; sialylation; glycan; mannose; convergence problems; n-glycan; prostate-specific membrane antigens; tetradecasaccharide; chemistry techniques, synthetic
Journal Title: Journal of the American Chemical Society
Volume: 134
Issue: 39
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2012-10-03
Start Page: 16430
End Page: 16433
Language: English
DOI: 10.1021/ja307628w
PROVIDER: scopus
PMCID: PMC3470013
PUBMED: 22954207
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84867080246&partnerID=40&md5=d377c4aa096692e55c2447b9c015c8a0
Notes: --- - "Export Date: 2 November 2012" - "CODEN: JACSA" - "Source: Scopus"
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MSK Authors
  1. Maciej A Walczak
    3 Walczak
  2. Samuel J Danishefsky
    539 Danishefsky
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