Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens Journal Article

  


Authors: Zhang, S.; Zhang, H. S.; Cordon-Cardo, C.; Reuter, V. E.; Singhal, A. K.; Lloyd, K. O.; Livingston, P. O.
Article Title: Selection of tumor antigens as targets for immune attack using immunohistochemistry: II. Blood group-related antigens
Abstract: Blood group-related antigens have been attractive targets for immunotherapy of cancer since their initial identification as cancer-related antigens. However, available information on the relative expression of most of these antigens on human malignant and normal tissues has been insufficient for selecting optimal antigens and tumors for immune attack. In this study, the distribution of the blood group-related antigens TF, Tn, sTn, Lea, sialyl Lea, Leb, Le(x), sialyl Le(x), polyfucosyl Le(x) and Le(y) on 13 types of cancer and 16 normal tissues was compared. Our results show that sTn is strongly expressed on cancers of breast, colon, stomach, ovary, prostate and uterus; Tn on prostate cancer; TF on cancers of breast, colon, ovary, prostate and uterus; Le(y) on the cancers of colon, lung, pancreas and ovary; Lea and Le(x) on gastric cancer; and sialyl Lea and sialyl Le(x) on colon cancer. The complete absence of these antigens on cancers of neuroectodermal or mesodermal origin including melanoma, sarcoma, neuroblastoma and B cell lymphoma is as striking as their widespread presence on tumors of epithelial origin. Normal tissues were also tested. Tn and Leb were only detected on gastric and ovarian epithelia; sTn on Leydig cells of testis in addition to gastric and ovarian epithelia; Le(x) and sialyl Le(x) on polymorphonuclear leukocytes; and TF, Lea, sialyl Lea, Le(x), sialyl Le(x), polyfucosyl Le(x) and Le(y) on epithelia from a variety of tissues.
Keywords: immunohistochemistry; human tissue; neoplasms; antigen expression; animals; mice; ovary cancer; breast cancer; leydig cell; prostate cancer; antibodies, monoclonal; antigens, neoplasm; antigen recognition; stomach cancer; uterus cancer; antigens, tumor-associated, carbohydrate; lewis blood-group system; cancer immunology; humans; human; priority journal; article
Journal Title: International Journal of Cancer
Volume: 73
Issue: 1
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 1997-09-26
Start Page: 50
End Page: 56
Language: English
DOI: 10.1002/(sici)1097-0215(19970926)73:1<50::aid-ijc9>3.0.co;2-0
PUBMED: 9334809
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030765682&doi=10.1002%2f%28SICI%291097-0215%2819970926%2973%3a1%3c50%3a%3aAID-IJC9%3e3.0.CO%3b2-0&partnerID=40&md5=4451b752ff22015fcac1dcaa0b939a39
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Victor Reuter
    1224 Reuter
  3. Philip O Livingston
    228 Livingston
  4. Kenneth O Lloyd
    163 Lloyd
  5. Shengle Zhang
    25 Zhang
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