Blood group and blood‐group‐related antigens in normal pancreas and pancreas cancer: Enhanced expression of precursor type 1, Tn and Sialyl‐Tn in pancreas cancer Journal Article

  

Authors:	Schuessler, M. H.; Pintado, S.; Welt, S.; Real, F. X.; Xu, M.; Melamed, M. R.; Lloyd, K. O.; Oettgen, H. F.
Article Title:	Blood group and blood‐group‐related antigens in normal pancreas and pancreas cancer: Enhanced expression of precursor type 1, Tn and Sialyl‐Tn in pancreas cancer
Abstract:	Expression of blood‐group antigens A, B, Lea, sialyl‐Lea (sLea), Leb, Lex, Ley, precursor type 1, Tn and sialyl‐Tn (sTn) was examined in non‐neoplastic pancreas (n = 37) and pancreas cancer (n = 21) using mouse monoclonal antibodies (MAbs). Immunohistochemical assays were performed on sections of paraffin‐embedded tissues using the avidin‐biotin complex method. In normal pancreas, antibodies detecting Lea, sLea and Tn reacted with ductal epithelium, and antibodies detecting A and B reacted with acini and ducts, independently of secretor status. Lex was weakly expressed in ducts and acini, and sTn could not be detected in normal pancreas. Expression of Leb, Ley and precursor type 1 was regulated by secretor status: Leb and Ley were expressed in ducts of secretor and Lea‐b− individuals, but not in ducts of non‐secretors; precursor type I was weakly expressed in acini and ducts of non‐secretors and Lea‐b− individuals, and was absent in acini and ducts of secretors. The following alterations in the expression of blood‐group antigens were observed in pancreas cancer: (1) enhanced expression of Lex, Tn and sTn; (2) enhanced expression of precursor type I independently of secretor status; (3) loss of regulation of Leb by the secretor gene; (4) decreased expression of Ley. The weak expression of precursor type 1, Tn and sTn in non‐neoplastic pancreas, and their stronger expression in pancreas cancer, suggests that up‐regulation of their expression is associated with malignant transformation of pancreatic duct cells. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
Keywords:	immunohistochemistry; controlled study; human tissue; major clinical study; pancreas cancer; pancreatic neoplasms; pancreas; antigen expression; tumor markers, biological; abo blood-group system; immunoenzyme techniques; antibodies, monoclonal; antigens, neoplasm; pancreas tumor; lewis blood-group system; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; blood group antigen; blood groups
Journal Title:	International Journal of Cancer
Volume:	47
Issue:	2
ISSN:	0020-7136
Publisher:	John Wiley & Sons
Date Published:	1991-01-21
Start Page:	180
End Page:	187
Language:	English
DOI:	10.1002/ijc.2910470204
PUBMED:	1988363
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025978318&doi=10.1002%2fijc.2910470204&partnerID=40&md5=5ecce0077caf835aee219985c18cfbe5
Notes:	Source: Scopus

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