Building biologics by chemical synthesis: Practical preparation of Di- and triantennary N-linked glycoconjugates Journal Article

   


Authors: Walczak, M. A.; Hayashida, J.; Danishefsky, S. J.
Article Title: Building biologics by chemical synthesis: Practical preparation of Di- and triantennary N-linked glycoconjugates
Abstract: A unified strategy for the syntheses of bi- and triantennary fully sialylated N-glycans is described. The synthesis capitalizes on a global glycosylation strategy that delivers the desired undeca- and tetradecasaccharide in excellent yields. Finally, conjugation of the glycan to PSMA oligopeptide is described. © 2013 American Chemical Society.
Keywords: prostate specific membrane antigen; chemistry; amino acid sequence; glycosylation; polysaccharides; oligopeptides; synthesis; synthesis (chemical); chemical synthesis; n-linked; glutamate carboxypeptidase ii; antigens, surface; conjugation; glycoconjugate; n-glycans; oligopeptide; glycan; glycoconjugates
Journal Title: Journal of the American Chemical Society
Volume: 135
Issue: 12
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2013-03-01
Start Page: 4700
End Page: 4703
Language: English
PROVIDER: scopus
PMCID: PMC3632434
PUBMED: 23461434
DOI: 10.1021/ja401385v
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84875716264&partnerID=40&md5=7d104bcca20ddd800da600c950412e00
Notes: --- - "Export Date: 1 May 2013" - "CODEN: JACSA" - ":doi 10.1021/ja401385v" - "Source: Scopus"
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MSK Authors
  1. Joji Hayashida
    2 Hayashida
  2. Maciej A Walczak
    3 Walczak
  3. Samuel J Danishefsky
    539 Danishefsky
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