Should patients with aggressive peripheral T-cell lymphoma all be treated the same?: No... well yes, ... but maybe not for long Journal Article
| Authors: | Moskowitz, A. J.; Lunning, M. A.; Horwitz, S. M. |
| Article Title: | Should patients with aggressive peripheral T-cell lymphoma all be treated the same?: No... well yes, ... but maybe not for long |
| Abstract: | The peripheral T-cell lymphomas represent about 15% to 20% of non-Hodgkin lymphomas and are marked by clinical and pathologic heterogeneity. The most common T-cell entities include peripheral T-cell lymphoma, not otherwise specified, angioimmunoblastic T-cell lymphoma, and anaplastic large cell lymphoma anaplastic lymphoma kinase-negative, which account for approximately 60% of T-cell lymphoma cases. Because of the rarity of T-cell lymphomas and lack of randomized prospective studies, treatment for these diseases is not well defined. Current treatment strategies draw from data from phase II studies, retrospective analyses, and personal experience. For fit patients who can tolerate treatment with curative intent, we treat peripheral T-cell lymphoma, not otherwise specified, angioimmunoblastic T-cell lymphoma, and anaplastic large cell lymphoma anaplastic lymphoma kinase-negative similarly with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)-based induction therapy followed by consolidation with autologous stem cell transplant. Given the marked differences in histology, biology, and clinical presentation for these diseases, it is likely that they should be approached differently. Furthermore, prognostic factors and degree of chemosensitivity as measured by FDG-PET (fluorodeoxyglucose positron emission tomography) should likely be used to guide patients along different treatment pathways. We have a long way to go toward perfecting the treatment for T-cell lymphoma. We believe that a uniform treatment approach for patients with aggressive T-cell lymphoma is not appropriate; however, we do not yet have enough data to support an individualized approach to treatment. Clinical and biologic prognostic factors, degree of chemosensitivity as measured by FDG-PET, and histology should all likely have a role in directing patients along different treatment pathways, but prospective studies are needed to confirm this. © 2012 by Lippincott Williams & Wilkins. |
| Keywords: | treatment response; overall survival; aurora kinase inhibitor; prednisone; clinical feature; histopathology; review; cisplatin; doxorubicin; treatment planning; gemcitabine; cytarabine; rituximab; drug megadose; positron emission tomography; treatment indication; medical decision making; carboplatin; progression free survival; bortezomib; multiple cycle treatment; etoposide; cyclophosphamide; dexamethasone; melphalan; vincristine; autologous stem cell transplantation; risk factor; carmustine; ifosfamide; protein tyrosine kinase inhibitor; peripheral t cell lymphoma; t cell lymphoma; nonhodgkin lymphoma; whole body radiation; methylprednisolone; large cell lymphoma; t-cell lymphoma; fluorodeoxyglucose; alemtuzumab; induction chemotherapy; personalized medicine; transplant; peripheral t-cell lymphoma; gallium; anaplastic large cell lymphoma; failure free survival; angioimmunoblastic t cell lymphoma; methylprednisolone sodium succinate; cancer prognosis; angioimmunoblastic t-cell lymphoma; not otherwise specified; chemokine receptor ccr antagonist; chemokine receptor ccr4 |
| Journal Title: | The Cancer Journal |
| Volume: | 18 |
| Issue: | 5 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2012-09-01 |
| Start Page: | 445 |
| End Page: | 449 |
| Language: | English |
| DOI: | 10.1097/PPO.0b013e31826aeeb2 |
| PROVIDER: | scopus |
| PUBMED: | 23006950 |
| PMCID: | PMC3968683 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "CODEN: CAJOC" - "Source: Scopus" |
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