A retrospective analysis of peripheral T-cell lymphoma treated with the intention to transplant in the first remission Journal Article

Authors: Mehta, N.; Maragulia, J. C.; Moskowitz, A.; Hamlin, P. A.; Lunning, M. A.; Moskowitz, C. H.; Zelenetz, A.; Matasar, M. J.; Sauter, C.; Goldberg, J.; Horwitz, S. M.
Article Title: A retrospective analysis of peripheral T-cell lymphoma treated with the intention to transplant in the first remission
Abstract: Background Peripheral T-cell lymphomas are aggressive lymphomas that have no standard treatment. Studies suggest that HD-ASCT in the first CR improves outcome. Few data exist regarding allo-HSCT in the first CR. Patients and Methods We retrospectively identified patients (2001-2011) with PTCL-not otherwise specified, angioimmunoblastic T-cell lymphoma, and anaplastic lymphoma kinase-negative anaplastic large cell lymphoma, initially treated with CHOP, CHOP-ICE (ifosfamide, carboplatin, etoposide), or other therapy with the intention to transplant in the first CR. Disease characteristics, therapy, progression-free survival (PFS), and OS were evaluated. Results Sixty-five patients were identified. PFS and OS were 38% and 52%, respectively, at 4 years. CHOP and CHOP-ICE regimens had similar outcomes. Treatment with allo-HSCT and HD-ASCT had OS at 4 years of 66% and 67%, respectively. Patients who did not proceed to transplant had OS of 27%. IPI score ≤ 2 and Prognostic Index for T-cell Lymphomas scores ≤ 1 predicted improved outcome. Combined analysis of interim response to CHOP and IPI score also predicted PFS and OS. Conclusion Our results support consolidation of first CR with transplantation. The addition of etoposide did not improve outcomes. Baseline IPI and interim response to CHOP can predict outcomes and guide decisions about transplantation in first CR in PTCL. Randomized trials are necessary to confirm the efficacy of this approach.
Keywords: transplantation; non-hodgkin's lymphoma; allogeneic; autologous; ptcl
Journal Title: Clinical Lymphoma, Myeloma and Leukemia
Volume: 13
Issue: 6
ISSN: 2152-2650
Publisher: Elsevier Inc.  
Date Published: 2013-12-01
Start Page: 664
End Page: 670
Language: English
DOI: 10.1016/j.clml.2013.07.005
PROVIDER: scopus
PUBMED: 24035712
Notes: --- - "Export Date: 2 December 2013" - "Source: Scopus"
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MSK Authors
  1. Craig Moskowitz
    374 Moskowitz
  2. Matthew Alexander Lunning
    26 Lunning
  3. Steven M Horwitz
    360 Horwitz
  4. Craig Steven Sauter
    166 Sauter
  5. Andrew D Zelenetz
    554 Zelenetz
  6. Alison Moskowitz
    147 Moskowitz
  7. Paul Hamlin
    173 Hamlin
  8. Matthew J Matasar
    121 Matasar
  9. Neha Mehta Shah
    18 Shah