Molecular definition of the identity and activation of natural killer cells Journal Article
| Authors: | Bezman, N. A.; Kim, C. C.; Sun, J. C.; Min-Oo, G.; Hendricks, D. W.; Kamimura, Y.; Best, J. A.; Goldrath, A. W.; Lanier, L. L.; Gautier, E. L.; Jakubzick, C.; Randolph, G. J.; Best, A. J.; Knell, J.; Miller, J.; Brown, B.; Merad, M.; Jojic, V.; Koller, D.; Cohen, N.; Brennan, P.; Brenner, M.; Shay, T.; Regev, A.; Fletcher, A.; Elpek, K.; Bellemare-Pelletier, A.; Malhotra, D.; Turley, S.; Jianu, R.; Laidlaw, D.; Collins, J. J.; Narayan, K.; Sylvia, K.; Kang, J.; Gazit, R.; Rossi, D. J.; Kim, F.; Rao, T. N.; Wagers, A.; Shinton, S. A.; Hardy, R. R.; Monach, P.; Heng, T.; Kreslavsky, T.; Painter, M.; Ericson, J.; Davis, S.; Mathis, D.; Benoist, C. |
| Article Title: | Molecular definition of the identity and activation of natural killer cells |
| Abstract: | Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8 + T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states. © 2012 Nature America, Inc. All rights reserved. |
| Keywords: | signal transduction; controlled study; nonhuman; molecular genetics; cd8+ t lymphocyte; t-lymphocytes; animal cell; mouse; animals; mice; cells, cultured; gene expression; gene expression profiling; animal experiment; animal model; gene function; cell differentiation; transcription, genetic; lymphocyte differentiation; lymphocyte activation; microarray analysis; nucleotide sequence; natural killer cell; killer cells, natural; virus infection; genetic code; cytomegalovirus; t lymphocyte activation; immunogenetics |
| Journal Title: | Nature Immunology |
| Volume: | 13 |
| Issue: | 10 |
| ISSN: | 1529-2908 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-08-19 |
| Start Page: | 1000 |
| End Page: | 1008 |
| Language: | English |
| DOI: | 10.1038/ni.2395 |
| PROVIDER: | scopus |
| PUBMED: | 22902830 |
| PMCID: | PMC3572860 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 2 November 2012" - "CODEN: NIAMC" - "Molecular Sequence Numbers: GENBANK: GSE15907" - "Source: Scopus" |
