The killer cell inhibitory receptor genomic region on human chromosome 19q13.4 Journal Article

  


Authors: Dupont, B.; Selvakumar, A.; Steffens, U.
Article Title: The killer cell inhibitory receptor genomic region on human chromosome 19q13.4
Abstract: Multiple genes encoding type I transmembrane molecules and belonging to the immunoglobulin superfamily have recently been localized to human chromosome 19q13.4. These include a family of genes encoding killer cell inhibitory receptors (KIR) expressed on natural killer (NK) cells and subsets of T-lymphocytes, immunoglobulin-like transcripts (ILT-1, -2 and 3) expressed on myeloid cells and subsets of lymphoid cells, the gp49 family of receptors expressed on mast cells and NK cells and the gene encoding human myeloid immunoglobulin A Fc receptor (CD89). The receptors have one to four extracellular immunoglobulin domains, and the ligands are known for some of these molecules. This includes the FcαR and KIRs of the p58/p50 and p70/p70Δ, but the ligands for many others are unknown. Except for CD89, each subfamily of receptors exist, in two forms, of which one has a long cytoplasmic domain containing one to four immunoreceptor tyrosine-based inhibitory motifs (ITIM) and another form with a short cytoplasmic tail without ITIMs. ITIM-containing receptors can recruit cytoplasmic tyrosine phosphatases and provide inhibitory signals for cell activation, whereas receptors with a 'short' tail induce activating signals. The 19q13.4 chromosomal region is therefore now emerging as the immunoglobulin superfamily linkage group of genes differentially expressed on hematopoietic cell lineages and encoding pairs of receptors with opposing effects on signal transduction pathways and effector functions in hematopoietic cells.
Keywords: signal transduction; review; animals; immunoglobulin gene; molecular sequence data; membrane glycoproteins; natural killer cell; killer cells, natural; chromosomes, human, pair 19; fc receptor; bone marrow cell; antigens, cd; genetic linkage; antigens, surface; multigene family; receptors, immunologic; immunoglobulin a; lymphoid cell; mast cell; chromosome 19q; immunoglobulin superfamily; receptors, fc; myeloid cell; humans; human; priority journal; killer cell inhibitory receptor; fc receptor for iga; gp49 receptor
Journal Title: Tissue Antigens
Volume: 49
Issue: 6
ISSN: 0001-2815
Publisher: Wiley-Blackwell Publishing, Inc.  
Date Published: 1997-06-01
Start Page: 557
End Page: 563
Language: English
PUBMED: 9234476
PROVIDER: scopus
DOI: 10.1111/j.1399-0039.1997.tb02802.x
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031009043&partnerID=40&md5=30fdec9536431a776de211e4a1892364
Notes: Review -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Annamalai Selvakumar
    66 Selvakumar
  2. Bo Dupont
    264 Dupont
  3. Uwe Steffens
    9 Steffens
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