Natural killer cell education in human health and disease Journal Article


Authors: Boudreau, J. E.; Hsu, K. C.
Article Title: Natural killer cell education in human health and disease
Abstract: Natural killer (NK) cells maintain immune homeostasis by detecting and eliminating damaged cells. Simultaneous activating and inhibitory input are integrated by NK cells, with the net signal prompting cytotoxicity and cytokine production, or inhibition. Chief among the inhibitory ligands for NK cells are ‘self’ human leukocyte antigen (HLA) molecules, which are sensed by killer immunoglobulin-like receptors (KIR). Through a process called ‘education’, the functional capabilities of each NK cell are counterbalanced by their sensitivity for inhibition by co-inherited ‘self’ HLA. HLA and their ligands, the killer immunoglobulin-like receptors (KIR), are encoded by polymorphic, polygenic gene loci that segregate independently, therefore, NK education and function differ even between related individuals. In this review, we describe how variation in NK education, reactivity and sensitivity for inhibition impacts reproductive success, infection, cancer, inflammatory and autoimmune diseases. © 2017 Elsevier Ltd
Journal Title: Current Opinion in Immunology
Volume: 50
ISSN: 0952-7915
Publisher: Elsevier Inc.  
Date Published: 2018-02-01
Start Page: 102
End Page: 111
Language: English
DOI: 10.1016/j.coi.2017.11.003
PROVIDER: scopus
PUBMED: 29413815
DOI/URL:
Notes: Review -- Export Date: 1 March 2018 -- Source: Scopus
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  1. Katharine C Hsu
    142 Hsu