Natural killer cell receptors: Regulating innate immune responses to hematologic malignancy Journal Article
| Authors: | Hsu, K. C.; Dupont, B. |
| Article Title: | Natural killer cell receptors: Regulating innate immune responses to hematologic malignancy |
| Abstract: | Critical to innate immunity, the natural killer (NK) cell performs its function of immunosurveillance through its recognition of altered or missing self on damaged, infected, or transformed malignant cells. NK cell receptors responsible for detection of human leukocyte antigen (HLA) class I and class I-like proteins on potential target cells transmit inhibitory and activating signals that integrate to determine NK cell function. Advances in the fields of NK cell receptor biology and immunogenetics have enhanced our understanding of NK cell target recognition and may now guide studies to determine NK cell effects in the clinical setting. Analysis of NK cell receptor-ligand relationships, such as the inhibitory killer immunoglobulin-like receptors (KIRs) and their HLA class I ligands, has revealed the potential for NK cell--mediated benefit in allogeneic hematopoietic stem cell transplantation for hematologic malignancies. © 2005 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; protein expression; review; genetic analysis; protein domain; protein function; animals; cell function; infection; biology; protein; gene locus; cytotoxicity; immunoregulation; hematologic malignancy; hematologic neoplasms; immune response; regulatory mechanism; cell transformation; molecular recognition; cancer cell; cell damage; hla antigen class 1; histocompatibility antigens class i; ligand; graft versus host reaction; allogeneic hematopoietic stem cell transplantation; natural killer cell; killer cells, natural; inhibition kinetics; target cell; cytotoxicity, immunologic; immunity; protein structure; immunosurveillance; structure analysis; cell activation; cell activity; hla antigen; cell killing; receptors, immunologic; hypothesis; alloimmunity; histocompatibility; tumor immunology; cell receptor; immunogenetics; lectin receptor |
| Journal Title: | Seminars in Hematology |
| Volume: | 42 |
| Issue: | 2 |
| ISSN: | 0037-1963 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2005-04-01 |
| Start Page: | 91 |
| End Page: | 103 |
| Language: | English |
| DOI: | 10.1053/j.seminhematol.2005.01.010 |
| PUBMED: | 15846575 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 24 October 2012" - "CODEN: SEHEA" - "Source: Scopus" |
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