Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy Journal Article

  

Authors:	Zakian, K. L.; Sircar, K.; Hricak, H.; Chen, H. N.; Shukla-Dave, A.; Eberhardt, S.; Muruganandham, M.; Ebora, L.; Kattan, M. W.; Reuter, V. E.; Scardino, P. T.; Koutcher, J. A.
Article Title:	Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy
Abstract:	PURPOSE: To determine whether hydrogen 1 magnetic resonance (MK) spectroscopic imaging can be used to predict aggressiveness of prostate cancer. MATERIALS AND METHODS: All patients gave informed consent according to an institutionally approved research protocol. A total of 123 patients (median age, 58 years; age range, 40-74 years) who underwent endorectal MR imaging and MR spectroscopic imaging between January 2000 and December 2002 were included. MR imaging and spectroscopy were performed by using combined pelvic phased-array and endorectal probe. Water and lipids were suppressed, and phase-encoded data were acquired with 6.2-mm resolution. Voxels in the peripheral zone were considered suspicious for cancer if (Cho + Cr)/Cit was at least two standard deviations above the normal level, where Cho represents choline-containing compounds, Cr represents creatine and phosphocreatine, and Cit represents citrate. Correlation between metabolite ratio and four Gleason score groups identified at step-section pathologic evaluation (3 + 3, 3 + 4, 4 + 3, and ≥4 + 4) was assessed with generalized estimating equations. RESULTS: Data from 94 patients were included. Pathologic evaluation was used to identify 239 lesions. Overall sensitivity of MR spectroscopic imaging was 56% for tumor detection, increasing from 44% in lesions with Gleason score of 3 + 3 to 89% in lesions with Gleason score greater than or equal to 4 + 4. There was a trend toward increasing (Cho + Cr)/Cit with increasing Gleason score in lesions identified correctly with MR spectroscopic imaging. Tumor volume assessed with MR spectroscopic imaging increased with increasing Gleason score. CONCLUSION: MR spectroscopic imaging measurement of prostate tumor (Cho + Cr)/Cit and tumor volume correlate with pathologic Gleason score. There is overlap between MR spectroscopic imaging parameters at various Gleason score levels, which may reflect methodologic and physiologic variations. MR spectroscopic imaging has potential in noninvasive assessment of prostate cancer aggressiveness. © RSNA, 2005.
Keywords:	adult; aged; middle aged; major clinical study; nuclear magnetic resonance imaging; sensitivity and specificity; tumor volume; clinical protocol; biopsy; prostate cancer; gleason score; prostatic neoplasms; prostatectomy; disease progression; measurement; predictive value of tests; magnetic resonance spectroscopy; choline; creatine; nuclear magnetic resonance spectroscopy; protons; signal processing, computer-assisted; roc curve; proton nuclear magnetic resonance; creatine phosphate
Journal Title:	Radiology
Volume:	234
Issue:	3
ISSN:	0033-8419
Publisher:	Radiological Society of North America, Inc.
Date Published:	2005-03-01
Start Page:	804
End Page:	814
Language:	English
DOI:	10.1148/radiol.2343040363
PUBMED:	15734935
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-13844296966&partnerID=40&md5=2231ec34860bc8af118a431b97be7b37
Notes:	--- - "Cited By (since 1996): 205" - "Export Date: 24 October 2012" - "CODEN: RADLA" - "Source: Scopus"

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