Transition zone prostate cancer: Metabolic characteristics at 1H MR spectroscopic imaging-initial results Journal Article


Authors: Zakian, K. L.; Eberhardt, S.; Hricak, H.; Shukla-Dave, A.; Kleinman, S.; Muruganandham, M.; Sircar, K.; Kattan, M. W.; Reuter, V. E.; Scardino, P. T.; Koutcher, J. A.
Article Title: Transition zone prostate cancer: Metabolic characteristics at 1H MR spectroscopic imaging-initial results
Abstract: PURPOSE: To determine whether cancers of the prostate transition zone (TZ) possess a unique metabolic pattern by which they may be identified at proton magnetic resonance (MR) spectroscopic imaging. MATERIALS AND METHODS: Findings in 40 patients who underwent combined endorectal MR imaging and hydrogen 1 MR spectroscopic imaging before radical prostatectomy and who had TZ tumor identified subsequently at step-section pathologic analysis were retrospectively reviewed. Within this population, a subset of 16 patients whose TZ tumor had a largest diameter of 1 cm or greater and was included in the MR spectroscopic imaging excitation volume was identified. In these 16 patients, the ratios of choline-containing compounds (Cho) and creatine/phosphocreatine (Cr) to citrate (Cit) (ie, [Cho + Cr]/Cit), Cho/Cr, and Cho/Cit were compared in tumor and control tissues. The presence of only Cho and the absence of all metabolites were also assessed. RESULTS: The mean values of (Cho + Cr)/Cit, Cho/Cr, and Cho/Cit were different between TZ cancer and control tissues (P = .001, P = .003, and P = .001, respectively; Wilcoxon signed rank test). Nine (56%) of 16 patients had at least one tumor voxel in which Cho comprised the only detectable peak, while no control voxels showed only Cho (P = .008, McNemar test). The percentage of voxels in which no metabolites were detected did not differ between tumor and control tissues (P = .134, McNemar test). CONCLUSION: TZ cancer has a metabolic profile that is different from that of benign TZ tissue; however, the broad range of metabolite ratios observed in TZ cancer precludes the use of a single ratio to differentiate TZ cancer from benign TZ tissue. © RSNA, 2003.
Keywords: adult; clinical article; controlled study; human tissue; aged; middle aged; retrospective studies; histopathology; magnetic resonance imaging; image analysis; prostate cancer; prostatic neoplasms; prostate; prostatectomy; prostate tumor; magnetic resonance spectroscopy; choline; citric acid; creatine; nuclear magnetic resonance spectroscopy; prostate hypertrophy; image reconstruction; proton nuclear magnetic resonance; creatine phosphate; phosphocreatine; humans; human; male; priority journal; article; prostate, mr; magnetic resonance (mr) spectroscopy; magnetic resonance (mr), tissue characterization; prostate, hyperplasia; prostate, neoplasms
Journal Title: Radiology
Volume: 229
Issue: 1
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 2003-10-01
Start Page: 241
End Page: 247
Language: English
DOI: 10.1148/radiol.2291021383
PUBMED: 12920178
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Peter T Scardino
    627 Scardino
  2. Kanishka Sircar
    7 Sircar
  3. Hedvig Hricak
    339 Hricak
  4. Amita Dave
    85 Dave
  5. Kristen L Zakian
    77 Zakian
  6. Jason A Koutcher
    241 Koutcher
  7. Victor Reuter
    999 Reuter
  8. Michael W Kattan
    218 Kattan