Performance characteristics of MR imaging in the evaluation of clinically low-risk prostate cancer: A prospective study Journal Article
| Authors: | Vargas, H.; Akin, O.; Shukla-Dave, A.; Zhang, J.; Zakian, K. L.; Zheng, J.; Kanao, K.; Goldman, D. A.; Moskowitz, C. S.; Reuter, V. E.; Eastham, J. A.; Scardino, P. T.; Hricak, H. |
| Article Title: | Performance characteristics of MR imaging in the evaluation of clinically low-risk prostate cancer: A prospective study |
| Abstract: | Purpose: To prospectively evaluate diagnostic performance of T2- weighted magnetic resonance (MR) imaging and MR spectroscopic imaging in detecting lesions stratified by pathologic volume and Gleason score in men with clinically determined low-risk prostate cancer. Materials and Methods: The institutional review board approved this prospective, HIPAA-compliant study. Written informed consent was obtained from 183 men with clinically low-risk prostate cancer (cT1-cT2a, Gleason score ≤ 6 at biopsy, prostatespecific antigen [PSA] level < 10 ng/mL [10 mg/L]) undergoing MR imaging before prostatectomy. By using a scale of 1-5 (score 1, definitely no tumor; score 5, definitely tumor), two radiologists independently scored likelihood of tumor per sextant on T2-weighted images. Two spectroscopists jointly recorded locations of lesions with metabolic features consistent with tumor on MR spectroscopic images. Whole-mount step-section histopathologic analysis constituted the reference standard. Diagnostic performance at sextant level (T2-weighted imaging) and detection sensitivities (T2-weighted imaging and MR spectroscopic imaging) for lesions of 0.5 cm3 or larger were calculated. Results: For T2-weighted imaging, areas under the receiver operating characteristic curves for sextant-level detection were 0.77 (reader 1) and 0.82 (reader 2). For lesions of ≥0.5 cm 3 and <1 cm 3, sensitivities were significantly lower when the lesion Gleason score was ≤6 (0.44 [reader 1] and 0.61 [reader 2]) rather than when the Gleason score was ≥7 (0.73, P = .02 [reader 1]; and 0.84, P = .05 [reader 2]). For lesions of ≥1 cm 3, lesion Gleason score did not significantly affect sensitivity (0.83 [reader 1] and 1.00 [reader 2] for Gleason score ≤ 6 vs 0.82 and 0.92 for Gleason score ≥ 7; P ≥ .07). MR spectroscopic imaging sensitivity was low and was not significantly affected by pathologic lesion volume or Gleason score. Conclusion: In men with clinically low-risk prostate cancer, detection of lesions of <1 cm 3 with T2-weighted imaging is significantly dependent on lesion Gleason score; detection of lesions of ≥1 cm 3 is significantly better than detection of smaller lesions and is not affected by lesion Gleason score. The role of MR spectroscopic imaging alone in this population is limited. © RSNA, 2012. |
| Keywords: | adult; child; controlled study; human tissue; school child; aged; middle aged; major clinical study; cancer risk; preoperative care; nuclear magnetic resonance imaging; diagnostic accuracy; prospective study; sensitivity and specificity; prospective studies; prostate specific antigen; reproducibility of results; image interpretation, computer-assisted; risk factors; prostate cancer; gleason score; prostatic neoplasms; image enhancement; prostatectomy; prostate biopsy; cancer size; nuclear magnetic resonance spectroscopy; intermethod comparison; rating scale; performance; predictive value; receiver operating characteristic; diagnostic test accuracy study; tissue metabolism |
| Journal Title: | Radiology |
| Volume: | 265 |
| Issue: | 2 |
| ISSN: | 0033-8419 |
| Publisher: | Radiological Society of North America, Inc. |
| Date Published: | 2012-11-01 |
| Start Page: | 478 |
| End Page: | 487 |
| Language: | English |
| DOI: | 10.1148/radiol.12120041 |
| PROVIDER: | scopus |
| PMCID: | PMC3480819 |
| PUBMED: | 22952382 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 December 2012" - "CODEN: RADLA" - "Source: Scopus" |
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