Organic synthesis in pursuit of immunology: Large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine Journal Article

  

Authors:	Young, S. C.; Wan, Q.; Danishefsky, S. J.
Article Title:	Organic synthesis in pursuit of immunology: Large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine
Abstract:	We describe herein the stereocontrolled, large-scale synthesis of peracetylated GM2 glycosylamino acid. Key features of the synthesis include a newly modified [1 + 3] coupling reaction and an olefin cross-metathesis- hydrogenation sequence. The GM2 glycosylamino acid is now ready for incorporation into a hexavalent prostate cancer vaccine construct. © 2005 Elsevier Ltd. All rights reserved.
Keywords:	unclassified drug; prostate cancer; prostatic neoplasms; immunology; molecular sequence data; cancer vaccine; cancer vaccines; magnetic resonance spectroscopy; amino acids; synthesis; carbohydrate sequence; acetylation; spectrophotometry, infrared; glycosylamino acid; hydrogenation; alkene; amino acid derivative
Journal Title:	Bioorganic & Medicinal Chemistry
Volume:	13
Issue:	17
ISSN:	0968-0896
Publisher:	Pergamon-Elsevier Science Ltd
Date Published:	2005-09-01
Start Page:	5259
End Page:	5266
Language:	English
DOI:	10.1016/j.bmc.2005.06.018
PUBMED:	16006132
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-22844444296&partnerID=40&md5=88ffeb8aea792ba8bbb1fe2d3a1f2d09
Notes:	--- - "Cited By (since 1996): 3" - "Export Date: 24 October 2012" - "CODEN: BMECE" - "Source: Scopus"

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