A paradigm case for the merging of glycal and enzymatic assembly methods in glycoconjugate synthesis: A highly efficient chemo-enzymatic synthesis of GM(3) Journal Article
| Authors: | Liu, K. K. C.; Danishefsky, S. J. |
| Article Title: | A paradigm case for the merging of glycal and enzymatic assembly methods in glycoconjugate synthesis: A highly efficient chemo-enzymatic synthesis of GM(3) |
| Abstract: | A concise, regio- and stereoselective synthesis of the ganglioside GM 3 has been achieved. Use of an α-1,2-oxirane derived from lactal facilitated installation of the anomeric β-ceramide side chain. Introduction of the sialic acid residue at C3′ of the lactose was accomplished regiospecifically by enzymatically mediated sialyl transfer from CMP-Neu-5-Ac. © VCH Verlagsgesellschaft mbH, 1996. |
| Keywords: | synthesis (chemical); carbohydrates; stereochemistry; glycosidations; gangliosides; stereoselectivity; glycoconjugates; anhydrosugars; enzymatic catalysis |
| Journal Title: | Chemistry - A European Journal |
| Volume: | 2 |
| Issue: | 11 |
| ISSN: | 0947-6539 |
| Publisher: | Wiley V C H Verlag Gmbh |
| Date Published: | 1996-11-01 |
| Start Page: | 1359 |
| End Page: | 1362 |
| Language: | English |
| DOI: | 10.1002/chem.19960021105 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
