Olefin cross-metathesis: A powerful tool for constructing vaccines composed of multimeric antigens Journal Article
| Authors: | Wan, Q.; Cho, Y. S.; Lambert, T. H.; Danishefsky, S. J. |
| Article Title: | Olefin cross-metathesis: A powerful tool for constructing vaccines composed of multimeric antigens |
| Abstract: | The preparation of biologically pertinent glycosylamino acids from O-pentenyl glycosides is described. The procedure involves sequential cross-metathesis reactions followed by hydrogenation. The generality and value of this procedure have been demonstrated by the preparation of peracetylated Gb3, GM2, and fucosyl GM1 glycosylamino acids, which are of potentially large value in the preparation of future anticancer vaccines. |
| Keywords: | antibodies; catalyst; carbohydrate; vaccines; keyhole limpet hemocyanin; isomerization; prostate-cancer; lung-cancer; induce; tumor-antigens; conjugate vaccine; pentenyl glycoside method; cancer patients; anticancer vaccines; cross-metathesis; glycosylamino acids; o-pentenyl glycosides; grubbs |
| Journal Title: | Journal of Carbohydrate Chemistry |
| Volume: | 24 |
| Issue: | 4-6 |
| ISSN: | 0732-8303 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2005-01-01 |
| Start Page: | 425 |
| End Page: | 440 |
| Language: | English |
| DOI: | 10.1081/car-200066992 |
| ACCESSION: | WOS:000231388300009 |
| PROVIDER: | wos |
| Notes: | --- - Article - "Source: Wos" |
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