C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production Journal Article
| Authors: | Tian, W.; Nunez, R.; Cheng, S.; Ding, Y.; Tumang, J.; Lyddane, C.; Roman, C.; Liou, H. C. |
| Article Title: | C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production |
| Abstract: | We are reporting the identification of a novel C-type lectin receptor-ligand pair that is involved in T cell costimulation. The receptor, OCILRP2/Clr-g, is rapidly induced following T cell activation and maintained at a substantial level of up to 72 h. The ligand, NKRP1f, is predominantly expressed on dendritic cells (DC). The soluble OCILRP2-Ig blocking protein significantly suppresses specific antigen-stimulated T cell proliferation as well as IL-2 secretion both in vitro and in vivo; conversely, NKRP1f-expressing antigen presenting cells (APC) enhance B7.1/CD28-mediated costimulation for T cell proliferation through interaction with OCILRP2/Clr-g. Our studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo. © 2005 Elsevier Inc. All rights reserved. |
| Keywords: | protein expression; unclassified drug; nonhuman; protein domain; protein function; cell proliferation; t lymphocyte; t-lymphocytes; animal cell; mouse; animals; mice; mice, knockout; animal tissue; cells, cultured; interleukin 2; spleen; dendritic cell; protein binding; membrane proteins; in vivo study; protein interaction; in vitro study; time factors; gene expression regulation; dendritic cells; kinetics; nucleotide sequence; ligand; ligands; immunostimulation; protein subunit; protein family; cell stimulation; protein isoforms; antigen presenting cell; cd28 antigen; rna splicing; interleukin-2; t lymphocytes; receptors, immunologic; costimulation; lectins, c-type; lectin; antigen presenting cells; c-type lectin; osteoclast inhibitory lectin related protein 2 |
| Journal Title: | Cellular Immunology |
| Volume: | 234 |
| Issue: | 1 |
| ISSN: | 0008-8749 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-03-01 |
| Start Page: | 39 |
| End Page: | 53 |
| Language: | English |
| DOI: | 10.1016/j.cellimm.2005.04.021 |
| PUBMED: | 15963483 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 24 October 2012" - "CODEN: CLIMB" - "Molecular Sequence Numbers: GENBANK: AY256574, AY256575, AY256576, NM_020257;" - "Source: Scopus" |
