C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production Journal Article

Authors: Tian, W.; Nunez, R.; Cheng, S.; Ding, Y.; Tumang, J.; Lyddane, C.; Roman, C.; Liou, H. C.
Article Title: C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production
Abstract: We are reporting the identification of a novel C-type lectin receptor-ligand pair that is involved in T cell costimulation. The receptor, OCILRP2/Clr-g, is rapidly induced following T cell activation and maintained at a substantial level of up to 72 h. The ligand, NKRP1f, is predominantly expressed on dendritic cells (DC). The soluble OCILRP2-Ig blocking protein significantly suppresses specific antigen-stimulated T cell proliferation as well as IL-2 secretion both in vitro and in vivo; conversely, NKRP1f-expressing antigen presenting cells (APC) enhance B7.1/CD28-mediated costimulation for T cell proliferation through interaction with OCILRP2/Clr-g. Our studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo. © 2005 Elsevier Inc. All rights reserved.
Keywords: protein expression; unclassified drug; nonhuman; protein domain; protein function; cell proliferation; t lymphocyte; t-lymphocytes; animal cell; mouse; animals; mice; mice, knockout; animal tissue; cells, cultured; interleukin 2; spleen; dendritic cell; protein binding; membrane proteins; in vivo study; protein interaction; in vitro study; time factors; gene expression regulation; dendritic cells; kinetics; nucleotide sequence; ligand; ligands; immunostimulation; protein subunit; protein family; cell stimulation; protein isoforms; antigen presenting cell; cd28 antigen; rna splicing; interleukin-2; t lymphocytes; receptors, immunologic; costimulation; lectins, c-type; lectin; antigen presenting cells; c-type lectin; osteoclast inhibitory lectin related protein 2
Journal Title: Cellular Immunology
Volume: 234
Issue: 1
ISSN: 0008-8749
Publisher: Elsevier Inc.  
Date Published: 2005-03-01
Start Page: 39
End Page: 53
Language: English
DOI: 10.1016/j.cellimm.2005.04.021
PUBMED: 15963483
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 13" - "Export Date: 24 October 2012" - "CODEN: CLIMB" - "Molecular Sequence Numbers: GENBANK: AY256574, AY256575, AY256576, NM_020257;" - "Source: Scopus"
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MSK Authors
  1. Clay   Lyddane
    10 Lyddane