Human dendritic cells: Potent antigen-presenting cells at the crossroads of innate and adaptive immunity Journal Article
| Authors: | Rossi, M.; Young, J. W. |
| Article Title: | Human dendritic cells: Potent antigen-presenting cells at the crossroads of innate and adaptive immunity |
| Abstract: | Dendritic cells (DCs) are specialized, bone marrow-derived leukocytes that are critical to the development of immunity. Investigators have emphasized the role of DCs in initiating adaptive or acquired MHC-restricted, Ag-specific T cell responses. More recent evidence supports important roles for DCs in the onset of innate immunity and peripheral tolerance. Progress in the generation of DCs from defined hemopoietic precursors in vitro has revealed the heterogeneity of these APCs and their attendant divisions of labor. This review will address these developments in an attempt to integrate the activities of different DCs in coordinating innate and adaptive immunity. Copyrighl © 2005 by The American Association of Immunologists, Inc. |
| Keywords: | human cell; clinical trial; drug efficacy; drug safety; t lymphocyte; cd34 antigen; dendritic cell vaccine; cell maturation; dendritic cell; immunological tolerance; antigen presentation; lymphocyte activation; dendritic cells; cellular immunity; immunotherapy; antigen specificity; cytotoxic t lymphocyte; natural killer cell; short survey; fc receptor; innate immunity; bone marrow cell; hematopoietic stem cell; immunity; indoleamine 2,3 dioxygenase; vaccine production; adaptive immunity; antigen presenting cell; immunotherapy, adoptive; toll like receptor; major histocompatibility antigen class 1; major histocompatibility complex restriction; immunity, cellular; antigen antibody complex; cross presentation; immunity, natural; adaptation; leukocyte activation; lectin receptor; opsonization |
| Journal Title: | Journal of Immunology |
| Volume: | 175 |
| Issue: | 3 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2005-08-01 |
| Start Page: | 1373 |
| End Page: | 1381 |
| Language: | English |
| PUBMED: | 16034072 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 139" - "Export Date: 24 October 2012" - "CODEN: JOIMA" - "Source: Scopus" |
