Dendritic cells in cancer immunology and immunotherapy Review
| Authors: | Wculek, S. K.; Cueto, F. J.; Mujal, A. M.; Melero, I.; Krummel, M. F.; Sancho, D. |
| Review Title: | Dendritic cells in cancer immunology and immunotherapy |
| Abstract: | Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much interest in modulating DC function to improve cancer immunotherapy. Many strategies have been developed to target DCs in cancer, such as the administration of antigens with immunomodulators that mobilize and activate endogenous DCs, as well as the generation of DC-based vaccines. A better understanding of the diversity and functions of DC subsets and of how these are shaped by the tumour microenvironment could lead to improved therapies for cancer. Here we will outline how different DC subsets influence immunity and tolerance in cancer settings and discuss the implications for both established cancer treatments and novel immunotherapy strategies. © 2019, Springer Nature Limited. |
| Keywords: | cancer chemotherapy; treatment response; review; drug efficacy; nonhuman; cancer radiotherapy; antineoplastic agent; cd8+ t lymphocyte; t lymphocyte; cell viability; cell function; dendritic cell vaccine; cancer immunotherapy; cell maturation; dendritic cell; in vivo study; cell differentiation; tumor antigen; cancer resistance; cytokine; immunological tolerance; antigen presentation; cancer immunization; cd4+ t lymphocyte; cell subpopulation; cell migration; tumor immunity; cytokine production; target cell; intestine flora; lymphatic drainage; cell activation; cell activity; adoptive immunotherapy; tumor microenvironment; cancer immunology; clonal anergy; lymphocyte transfer; human; priority journal; malignant neoplasm |
| Journal Title: | Nature Reviews Immunology |
| Volume: | 20 |
| Issue: | 1 |
| ISSN: | 1474-1733 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2020-01-01 |
| Start Page: | 7 |
| End Page: | 24 |
| Language: | English |
| DOI: | 10.1038/s41577-019-0210-z |
| PUBMED: | 31467405 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
