Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides Journal Article
| Authors: | Wang, P.; Li, X.; Zhu, J.; Chen, J.; Yuan, Y.; Wu, X.; Danishefsky, S. J. |
| Article Title: | Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides |
| Abstract: | Described herein is a method for the joining of complex peptides to complex oligosaccharides via an N-linkage. The ω-aspartylation is conducted by coupling fully deprotected glycosylamine with a peptide containing a unique thioacid at the ω-aspartate carboxyl. In the presence of HOBT, under conditions that, in principle, allow for oxidation, complex components are combined in encouraging yields to produce structurally and stereochemically defined N-linked glycopolypeptides wherein the carbohydrate domain can be quite complex. Various mechanisms for oxidative coupling are proposed. © 2011 American Chemical Society. |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 133 |
| Issue: | 5 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2011-02-09 |
| Start Page: | 1597 |
| End Page: | 1602 |
| Language: | English |
| DOI: | 10.1021/ja110115a |
| PROVIDER: | scopus |
| PMCID: | PMC3033444 |
| PUBMED: | 21207981 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 March 2011" - "CODEN: JACSA" - "Source: Scopus" |
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